Recombinant Human MARCKS-like 1, His-tagged MARCKSL1-526H

Recombinant Human MARCKS-like 1, His-tagged

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Recombinant Human MARCKS-like 1, His-tagged

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Cat.No. : MARCKSL1-526H
Product Overview : MARCKSL1, 1-195aa , Human, His tag, E.coli
Description : MARCKS-related protein, also known as MARCKSL1, is a member of MARCKS family of PKC substrate. It is widely used in the signal transduction studies as an indicator of PKC activation. Expressed in a variety of tissues with highest levels found in testis and uterus, MARCKSL1 participates in the coordination of membrane-cytoskeletal signaling events, including secretion, migration, phagocytosis and cell adhesion. Additionally, MARCKSL1 functions as a regulator of Integrin activation and is thought to regulate Integrin-dependent signal transduction pathways, especially those involved in macrophage spreading. Recombinant human MARCKSL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol
Molecular Mass : 21.9kDa (218aa) confirmed by MALDI-TOF(Molecular weight on SDS-PAGE will appear higher)
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMGSQSSK APRGDVTAEE AAGASPAKAN GQENGHVKSN GDLSPKGEGE SPPVNGTDEA AGATGDAIEP APPSQGAEAK GEVPPKETPK KKKKFSFKKP FKLSGLSFKR NRKEGGGDSS ASSPTEEEQE QGEIGACSDE GTAQEGKAAA TPESQEPQAK GAEASAASEE EAGPQATEPS TPSGPESGPT PASAEQNE
Purity : >90% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 0.25 mg/ml (determined by BCA assay)
Gene Name : MARCKSL1 MARCKS-like 1 [ Homo sapiens ]
Official Symbol : MARCKSL1
Synonyms : MARCKSL1; MARCKS-like 1; MARCKS like protein , MLP; MARCKS-related protein; F52; MacMARCKS; MLP1; mac-MARCKS; MARCKS-like protein 1; macrophage myristoylated alanine-rich C kinase substrate; MLP; MRP; MACMARCKS;
Gene ID : 65108
mRNA Refseq : NM_023009
Protein Refseq : NP_075385
MIM : 602940
UniProt ID : P49006
Chromosome Location : 1p35.1
Pathway : Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; Leishmaniasis, organism-specific biosystem; Leishmaniasis, conserved biosystem;
Function : calmodulin binding;

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