"SNIP1" Related Products

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Recombinant Human Smad nuclear interacting protein 1, His-tagged

Cat.No. : SNIP1-692H
Product Overview : SNIP1, 258-396aa, Human, His tag, E.coli
Description : SNIP1 is smad nuclear interacting protein contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. This protein is an inhibitor of the TGF-beta signal transduction pathway and to be important in suppressing transcriptional activation dependent on the co-activators CBP and p300. Inhibition of NF-kappa B activity is a function of the N-terminal domain of SNIP1 and involves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for binding to p300, similar to the mechanism of inhibition of Smad signaling by SNIP1. Recombinant human SNIP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 100mM NaCl
Molecular Mass : 18.8kDa (160aa) confirmed by MALDI-TOF
AA Sequence : MGSSHHHHHH SSGLVPRGSH MRWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVF QYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDT SEIDRKDDED EEEEEEVSDS
Purity : >90% by SDS - PAGE
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 1mg/ml (determined by Bradford assay)
Gene Name : SNIP1 Smad nuclear interacting protein 1 [ Homo sapiens ]
Official Symbol : SNIP1
Synonyms : SNIP1; Smad nuclear interacting protein 1; smad nuclear-interacting protein 1; FHA domain-containing protein SNIP1; PMRED; FLJ12553;
Gene ID : 79753
mRNA Refseq : NM_024700
Protein Refseq : NP_078976
MIM : 608241
UniProt ID : Q8TAD8
Chromosome Location : 1p34.3
Pathway : Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem;
Function : protein binding;

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