"ACVR1" Related Products

Recombinant Canine ACVR1, Fc-tagged

Cat.No.: ACVR1-160C
Product Overview: A DNA sequence encoding the canine ACVR1 (XP_549615.2) (Met1-Glu123) was expressed with the Fc region of human IgG1 at the C-terminus.
Description: Cytokines and hormones belonging to the transforming growth factor beta (TGFβ) superfamily such as the activin, anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal, are involved in a variety of physiological processes including growth, cell differentiation, homeostasis, osteogenesis, and apoptosis. They initiate signaling through heteromeric complexes of a type I and a type I I serine/threonine kinase receptor. The two type receptors are type I transmembrane proteins and are distinguished by the presence of a glycine/serine-rich juxta-membrane domain found in the type I receptors. Type II receptors are required for binding ligands and recruitment of type I receptors which then form stable complexes, and type I receptors are essential for signaling transduction. ALK2, also termed as ACVR1, ActRI, SKR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or IIB. In addition, ALK2 is also identified as a BMP type I receptor. ACVR1 has been demonstrated to form complex with either the BMP-2/7-bound BMPR-II or ACVR2A/ACVR2B and transduce signals to downstream components R-SMADs. Recombinant soluble ALK2 does not bind activin. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
Source: Human Cells
Species: Canine
Tag: Fc
Form: Lyophilized from sterile PBS, pH7.4.
Molecular Mass: The recombinant canine ACVR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 344 amino acids and has a predicted molecular mass of 38.6 kDa. The apparent molecular mass of the protein is approximately 68 and 44 kDa in SDS-PAGE under reducing conditions.
Protein length: Met1-Glu123
Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
Purity: (32.9+66.0) % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name: ACVR1 activin A receptor, type I [ Canis lupus familiaris ]
Official Symbol: ACVR1
Synonyms: ACVR1; activin A receptor, type I; activin receptor type-1;
Gene ID: 478757
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem;

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