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Recombinant Canine IL11RA, His-tagged

Cat.No. : IL11RA-173C
Product Overview : A DNA sequence encoding the canine IL11RA (XP_005626799.1) (Met1-Leu363) was expressed with a C-terminal polyhistidine tag.
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  • Gene Information
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Source : Human Cells
Species : Canine
Tag : His
Form : Lyophilized from sterile PBS, pH7.4.
Molecular Mass : The recombinant canine IL11RA comprises 352 amino acids and has a predicted molecular mass of 38.4 kDa. The apparent molecular mass of the protein is approximately 47.7 kDa in SDS-PAGE under reducing conditions.
Protein length : Met1-Leu363
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >90 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70℃
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : IL11RA interleukin 11 receptor, alpha [ Canis lupus familiaris ]
Official Symbol : IL11RA
Synonyms : IL11RA; interleukin 11 receptor, alpha; interleukin-11 receptor subunit alpha;
Gene ID : 481588
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Can you explain how phosphoproteomics and mass spectrometry shed light on IL11RA-mediated signaling cascades and post-translational modifications? 04/16/2022

Phosphoproteomics and mass spectrometry reveal IL11RA-related signaling pathways.

How are flow cytometry and fluorescence-activated cell sorting (FACS) employed to analyze IL11RA expression on different cell populations? 07/13/2021

Flow cytometry and FACS analyze IL11RA expression on different cell types.

Could you elaborate on how X-ray crystallography and cryo-electron microscopy contribute to understanding the three-dimensional structure of IL11RA? 06/12/2020

X-ray crystallography and cryo-EM reveal the three-dimensional structure of IL11RA.

What insights have gene expression profiling and RNA sequencing provided regarding IL11RA-related molecular pathways and networks? 09/10/2019

Gene expression profiling and RNA sequencing unveil IL11RA-associated molecular networks.

How do techniques like co-immunoprecipitation and pull-down assays validate IL11RA's interactions with IL11 and other signaling partners? 08/29/2019

Co-immunoprecipitation and pull-down assays confirm IL11RA interactions with IL11 and other partners.

What role does site-directed mutagenesis play in identifying IL11RA residues critical for IL11 binding and downstream signaling activation? 07/28/2019

Site-directed mutagenesis identifies IL11RA residues crucial for binding and signaling.

How are animal models like transgenic mice and tissue-specific knockouts utilized to study the in vivo roles of IL11RA in development and disease? 05/18/2019

Transgenic mice and knockouts study IL11RA's roles in development and disease.

Can you explain the experimental strategies used to characterize IL11RA isoforms and their differential roles in IL11 signaling? 04/08/2018

Experimental strategies characterize IL11RA isoforms and their distinct roles in IL11 signaling.

How are biophysical techniques such as isothermal titration calorimetry and surface plasmon resonance used to determine IL11RA's binding affinities and kinetics? 03/08/2018

Isothermal titration calorimetry and surface plasmon resonance measure IL11RA binding properties.

What methods like CRISPR-Cas9 knockout and RNA interference help elucidate the functional significance of IL11RA in specific biological contexts? 10/18/2017

CRISPR-Cas9 knockout and RNA interference reveal IL11RA's functions in specific contexts.

Customer Reviews (3)

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Reviews
02/15/2021

    High affinity binding.

    09/05/2020

      Stable in solution.

      02/20/2017

        Effective in hematopoiesis studies.

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