Recombinant Cynomolgus TEK, Fc-tagged TEK-212C

Recombinant Cynomolgus TEK, Fc-tagged

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Recombinant Cynomolgus TEK, Fc-tagged

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Cat.No. : TEK-212C
Product Overview : A DNA sequence encoding the cynomolgus TEK (G7PS68) (Met1-Lys745) was expressed with the Fc region of human IgG1 at the C-terminus.
Description : Tie2/Tek, together with Tie1/Tie, are members of the receptor tyrosine kinase (RTK) subfamily, and possess a unique extracellular domain containing two immunoglobulin-like loop domains flanking three epidermal growth factor (EGF) repeats followed by three fibronectin-type I?II repeats, and a split tyrosine kinase domain in the cytoplasmic region. Tie2 is expressed predominantly on endothelial and hematopoietic progenitor cells and is essential for blood vessel formation and maintenance. The identified ligand angiopoietin-1 (Ang-1) binds Tie2 receptor with highaffinity and induces the signaling pathway of both cell migration and cellsurvival via the related mediator such as GRB2 and SH-PTP2. Accordingly, the Tie2 may trigger crucial endothelial responses duringembryonic vascular development and during pathologic vascular growth, as well as the inflammatory responses with the key regulator ABIN-2. Recent study has revealed that Ang1-Tie2 signaling exerts different function at cell-cell contacts and cell-substratum contacts dependent upon the spatial localization of Tie2. Deficiency in this gene is associated with inherited venous malformations.
Source : Human Cells
Species : Cynomolgus
Tag : Fc
Form : Lyophilized from sterile PBS, pH7.4.
Molecular Mass : The recombinant cynomolgus TEK is a disulfide-linked homodimer. The reduced monomer comprises 964 amino acids and has a calculated molecular mass of 107.6 KDa.The apparent molecular mass of the protein is approximately 63 KDa respectively in SDS-PAGE.
Protein length : Met1-Lys745
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >95 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70℃
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : TEK TEK tyrosine kinase, endothelial [ Macaca fascicularis (crab-eating macaque) ]
Official Symbol : TEK
Synonyms : TEK; TEK tyrosine kinase, endothelial
Gene ID : 102122204
mRNA Refseq : XM_005581588
Protein Refseq : XP_005581645
Chromosome Location : 15
Pathway : HIF-1 signaling pathway; PI3K-Akt signaling pathway; Rap1 signaling pathway

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