Recombinant Cynomolgus HAVCR2, Fc-tagged HAVCR2-213C

Recombinant Cynomolgus HAVCR2, Fc-tagged


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Recombinant Cynomolgus HAVCR2, Fc-tagged

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Cat.No. : HAVCR2-213C
Product Overview : A DNA sequence encoding the cynomolgus TIM3 (EHH54703.1) (Met1-Arg201) was expressed with the Fc region of human IgG1 at the C-terminus.
Description : Hepatitis A virus cellular receptor 2 ( HAVCR2 ), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. TIM-3 thus serves as the surface molecule that distinguishes between the two effector populations derived from naive CD4(+) T-helper cells. TIM-3 is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. Th1 cells produce cytokines ( IFN-gamma, interleukin-2, TNF-alpha and lymphotoxin ) that are commonly associated with cellmediated immune responses against intracellular pathogens, delayedtype hypersensitivity reactions, and induction of organ-specific autoimmune diseases. It has been identified that galectin-9 is the Tim-3 ligand, and the TIM-3-galectin-9 pathway may serve to inhibit Th1 cellsduring a normal immune response and may be crucial for the induction of peripheral tolerance. Dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
Source : Human Cells
Species : Cynomolgus
Tag : Fc
Form : Lyophilized from sterile PBS, pH7.4.
Molecular Mass : The recombinant cynomolgus TIM3 comprises 418 amino acids and has a calculated molecular mass of 46.4 KDa. The apparent molecular mass of the protein is approximately 60.5 and 35.8 KDa in SDS-PAGE.
Protein length : Met1-Arg201
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : (70.9+26.4) % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70℃
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : HAVCR2?hepatitis A virus cellular receptor 2 [?Macaca fascicularis?(crab-eating macaque) ]
Official Symbol : HAVCR2
Synonyms : HAVCR2; hepatitis A virus cellular receptor 2
Gene ID : 102141722
mRNA Refseq : XM_005558381
Protein Refseq : XP_005558438
Chromosome Location : 6

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