Recombinant Human XIAP, His-tagged
Cat.No. : | XIAP-410H |
Product Overview : | A DNA sequence encoding the human BIR3 domain of XIAP (P29218-1) (Asn252-Thr356) was expressed with a polyhistidine tag at the N-terminus. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized from sterile PBS, pH7.4. |
Molecular Mass : | The recombinant human BIR3 domain of XIAP consists of 123 amino acids and predicts a molecular mass of 14.3 KDa. It migrates as an approximately 14.8 KDa band in SDS-PAGE under reducing conditions. |
Protein length : | Asn252-Thr356 |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >95 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70℃ |
Storage : | Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Hardcopy of COA with reconstitution instruction is sent along with the products. |
Gene Name : | XIAP X-linked inhibitor of apoptosis [ Homo sapiens ] |
Official Symbol : | XIAP |
Synonyms : | XIAP; X-linked inhibitor of apoptosis; API3, baculoviral IAP repeat containing 4 , BIRC4; baculoviral IAP repeat-containing protein 4; hILP; X-linked IAP; IAP-like protein; E3 ubiquitin-protein ligase XIAP; inhibitor of apoptosis protein 3; baculoviral IAP repeat-containing 4; X-linked inhibitor of apoptosis protein; API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3; FLJ26913; |
Gene ID : | 331 |
mRNA Refseq : | NM_001167 |
Protein Refseq : | NP_001158 |
MIM : | 300079 |
UniProt ID : | P98170 |
Chromosome Location : | Xq25 |
Pathway : | Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic factor-mediated response, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; |
Function : | cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ligase activity; metal ion binding; peptidase inhibitor activity; protein binding; ubiquitin-protein ligase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
XIAP-6266R | Recombinant Rat XIAP Protein, His (Fc)-Avi-tagged | +Inquiry |
XIAP-0712H | Recombinant Human XIAP Protein (Y120-P260), GST tagged | +Inquiry |
XIAP-399H | Recombinant Human XIAP Protein, MYC/DDK-tagged | +Inquiry |
XIAP-2873H | Recombinant Human Full length XIAP protein(1-497 aa), C-His-tagged | +Inquiry |
XIAP-2365H | Recombinant Human XIAP Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
XIAP-263HCL | Recombinant Human XIAP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, mutations in XIAP are associated with X-linked lymphoproliferative syndrome type 2 (XLP-2), a rare immunodeficiency disorder.
Yes, several clinical trials are investigating XIAP-targeted therapies for cancer, autoimmune diseases, and immunodeficiency disorders.
XIAP inhibitors are being explored as potential treatments for cancer to sensitize cancer cells to apoptosis-inducing therapies.
XIAP can be targeted using small molecule inhibitors and gene therapy to modulate apoptosis in various diseases.
Dysregulation of XIAP has been associated with autoimmune diseases, and its modulation may be a therapeutic strategy in such conditions.
Customer Reviews (3)
Write a reviewWith their assistance, I am confident in overcoming challenges, producing robust results, and advancing our understanding of XIAP protein and its biological significance.
In addition to the impeccable protein quality, the manufacturer provides excellent technical support that can effectively address any challenges I may encounter during my experiments.
The technical support provided by the manufacturer is invaluable in resolving any potential roadblocks and optimizing the utilization of XIAP protein.
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