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Recombinant Human XIAP, His-tagged

Cat.No. : XIAP-410H
Product Overview : A DNA sequence encoding the human BIR3 domain of XIAP (P29218-1) (Asn252-Thr356) was expressed with a polyhistidine tag at the N-terminus.
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  • Gene Information
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Source : E. coli
Species : Human
Tag : His
Form : Lyophilized from sterile PBS, pH7.4.
Molecular Mass : The recombinant human BIR3 domain of XIAP consists of 123 amino acids and predicts a molecular mass of 14.3 KDa. It migrates as an approximately 14.8 KDa band in SDS-PAGE under reducing conditions.
Protein length : Asn252-Thr356
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >95 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70℃
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : XIAP X-linked inhibitor of apoptosis [ Homo sapiens ]
Official Symbol : XIAP
Synonyms : XIAP; X-linked inhibitor of apoptosis; API3, baculoviral IAP repeat containing 4 , BIRC4; baculoviral IAP repeat-containing protein 4; hILP; X-linked IAP; IAP-like protein; E3 ubiquitin-protein ligase XIAP; inhibitor of apoptosis protein 3; baculoviral IAP repeat-containing 4; X-linked inhibitor of apoptosis protein; API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3; FLJ26913;
Gene ID : 331
mRNA Refseq : NM_001167
Protein Refseq : NP_001158
MIM : 300079
UniProt ID : P98170
Chromosome Location : Xq25
Pathway : Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic factor-mediated response, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem;
Function : cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ligase activity; metal ion binding; peptidase inhibitor activity; protein binding; ubiquitin-protein ligase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any clinical conditions associated with XIAP mutations? 04/20/2022

Yes, mutations in XIAP are associated with X-linked lymphoproliferative syndrome type 2 (XLP-2), a rare immunodeficiency disorder.

Are there any ongoing clinical trials involving XIAP-targeted therapies? 08/22/2020

Yes, several clinical trials are investigating XIAP-targeted therapies for cancer, autoimmune diseases, and immunodeficiency disorders.

Can XIAP inhibitors be used to treat cancer? 11/21/2019

XIAP inhibitors are being explored as potential treatments for cancer to sensitize cancer cells to apoptosis-inducing therapies.

How can XIAP be targeted for clinical applications? 12/02/2018

XIAP can be targeted using small molecule inhibitors and gene therapy to modulate apoptosis in various diseases.

In what way can XIAP be linked to autoimmune diseases? 11/16/2017

Dysregulation of XIAP has been associated with autoimmune diseases, and its modulation may be a therapeutic strategy in such conditions.

Customer Reviews (3)

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Reviews
03/09/2021

    With their assistance, I am confident in overcoming challenges, producing robust results, and advancing our understanding of XIAP protein and its biological significance.

    06/23/2018

      In addition to the impeccable protein quality, the manufacturer provides excellent technical support that can effectively address any challenges I may encounter during my experiments.

      10/28/2017

        The technical support provided by the manufacturer is invaluable in resolving any potential roadblocks and optimizing the utilization of XIAP protein.

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