"IL10" Related Products

Recombinant Pig IL10

Cat.No.: IL10-569P
Product Overview: A DNA sequence encoding the porcine IL10 (Q29055) (Ser19-Asn175) was expressed with an initial Met at the N-terminal.
Description: Interleukin-10, also known as cytokine synthesis inhibitory factor, CSIF and IL-10, is a secreted protein which belongs to the IL-10 family. Interleukin-10 / IL-10 is produced by a variety of cell lines, including Tcells, macrophages, mast cells and other cell types. It can also be produced by monocytes upon PD-1 triggering in this cells. Interleukin-10 / IL-10 inhibits the synthesis of a number of cytokines, including IFNgamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Interleukin-10 / IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies suggested the function of Interleukin-10 / IL-10 as an essential immunoregulator in the intestinal tract. Patients with Crohn"s disease react favorably towards treatment with bacteria producing recombinant interleukin-10, showing the importance of interleukin-10 for counteracting excessive immunity in the human body.
Source: E. coli
Species: Pig
Form: Lyophilized from sterile PBS, pH7.4.
Bio-activity: 1. Immobilized porcineIL10 at 10 μg/ml (100 μl/well) can bind Cynomolgus IL10RA-Fc, The EC50 of Cynomolgus IL10RA-Fc is 0.14-0.34 μg/ml.2. Measured in a cell proliferation assay using MC/9-2 mouse mast cells. The ED50 for this effect is typically 1-5 ng/
Molecular Mass: The recombinant porcine IL10 consists of 158 amino acids and has a predicted molecular mass of 18.2 kDa. The apparent molecular mass of it is approximately 18 kDa in SDS-PAGE under reducing conditions.
Protein length: Ser19-Asn175
Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
Purity: >95 % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name: IL10 interleukin 10 [ Sus scrofa ]
Official Symbol: IL10
Synonyms: IL10; interleukin 10; interleukin-10; cytokine synthesis inhibitory factor; CSIF; IL-10;
Gene ID: 397106
mRNA Refseq: NM_214041
Protein Refseq: NP_999206
Pathway: African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Asthma, organism-specific biosystem;

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