Recombinant Human MEK6, GST-tagged
Cat.No. : | MAP2K6-47H |
Product Overview : | Recombinant full-length human MEK6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | MEK6 or MAP2K6(mitogen-activated protein kinase kinase 6) is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase that also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. MEK6 phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, MEK6 is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~64 kDa |
Applications : | Kinase Assay, Western Blot |
Storage : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | MAP2K6 mitogen-activated protein kinase kinase 6 [ Homo sapiens ] |
Official Symbol : | MAP2K6 |
Synonyms : | MAP2K6; mitogen-activated protein kinase kinase 6; PRKMK6; dual specificity mitogen-activated protein kinase kinase 6; MAPKK6; MEK6; MKK6; protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); SAPKK3; MEK 6; MAPKK 6; SAPK kinase 3; MAPK/ERK kinase 6; stress-activated protein kinase kinase 3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPKK-3; |
Gene ID : | 5608 |
mRNA Refseq : | NM_002758 |
Protein Refseq : | NP_002749 |
MIM : | 601254 |
UniProt ID : | P52564 |
Chromosome Location : | 17q |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; CDC42 signaling events, organism-specific biosystem; CDO in myogenesis, organism-specific biosystem; CXCR3-mediated signaling events, organism-specific biosystem; Cellular roles of Anthrax toxin, organism-specific biosystem; |
Function : | ATP binding; MAP kinase kinase activity; nucleotide binding; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; |
Products Types
◆ Recombinant Protein | ||
MAP2K6-392H | Recombinant Human MAP2K6 Protein, MYC/DDK-tagged | +Inquiry |
MAP2K6-5326M | Recombinant Mouse MAP2K6 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAP2K6-2485R | Recombinant Rhesus Macaque MAP2K6 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAP2K6-1355H | Recombinant Human MAP2K6 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAP2K6-01H | Recombinant Human MAP2K6 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
MAP2K6-001HCL | Recombinant Human MAP2K6 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionIts expression levels in certain cancers are being explored as predictive biomarkers to anticipate response to specific therapies.
Studies also suggest its involvement in cardiovascular diseases and neurological disorders.
MAP2K6 signaling pathways might play a role in drug resistance mechanisms, making it a focus for overcoming therapeutic challenges.
Yes, mutations in MAP2K6 have been linked to certain cancers, including colorectal cancer and lung adenocarcinoma.
As with any targeted therapy, MAP2K6 inhibitors might have side effects, which are under investigation in preclinical and clinical studies.
Customer Reviews (3)
Write a reviewI am certain that the MAP2K6 protein will play a pivotal role in facilitating robust and insightful research, providing the assurance of reliable and consistent results.
The excellent technical support provided by the manufacturer can solve my problem.
Whether I am studying protein-protein interactions, investigating cellular pathways, or examining protein folding dynamics, the MAP2K6 protein consistently delivers exceptional performance and precise outcomes.
Ask a Question for All MAP2K6 Products
Required fields are marked with *
My Review for All MAP2K6 Products
Required fields are marked with *
Inquiry Basket