Recombinant Human FGFR3 (V555M), GST-tagged FGFR3-59H

Recombinant Human FGFR3 (V555M), GST-tagged

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Recombinant Human FGFR3 (V555M), GST-tagged

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Cat.No. : FGFR3-59H
Product Overview : Recombinant human FGFR3 (V555M) (397-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : Fibroblast growth factor receptor 3 (FGFR3) is part of a family of fibroblast growth factor receptors that share similar structure and function. FGFR3 plays a role in several important cellular processes, including regulation of cell growth and division, determination of cell fate, formation of blood vessels, wound healing and embryo development. FGFR3 is involved in the development and maintenance of bone and brain tissue. Mutations in FGFR3 have been implicated in causing bladder cancer, cancer of white blood cells (multiple myeloma) and cervical cancer.
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~73 kDa
Applications : Kinase Assay
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens ]
Official Symbol : FGFR3
Synonyms : FGFR3; fibroblast growth factor receptor 3; ACH, achondroplasia, thanatophoric dwarfism; CD333; CEK2; JTK4; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; ACH; HSFGFR3EX;
Gene ID : 2261
mRNA Refseq : NM_000142
Protein Refseq : NP_000133
MIM : 134934
UniProt ID : P22607
Chromosome Location : 4p16.3
Pathway : Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; FGFR ligand binding and activation, organism-specific biosystem;
Function : ATP binding; fibroblast growth factor binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; nucleotide binding; protein binding; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity;

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