Recombinant Human ACOT2, His-tagged

• Cat.No.: ACOT2-3139H
• Product Overview: Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2)

Specification

• Description: This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants.
• Source: E. Coli or Yeast
• Species: Human
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 483
• Purity: >90%
• Notes: Small volumes of ACOT2 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: ACOT2 acyl-CoA thioesterase 2 [ Homo sapiens ]
• Official Symbol: ACOT2
• Synonyms: ACOT2; MTE1; PTE2; CTE1A; PTE2A; CTE-IA; ZAP128; acyl-coenzyme A thioesterase 2, mitochondrial; long-chain acyl-CoA thioesterase 2; mitochondrial acyl-CoA thioesterase 1; acyl-coenzyme A thioester hydrolase 2a; peroxisomal long-chain acyl-coA thioesterase 2
• Gene ID: 10965
• mRNA Refseq: NM_006821
• Protein Refseq: NP_006812
• MIM: 609972
• UniProt ID: P49753
• Chromosome Location: 14q24.3
• Pathway: Biosynthesis of unsaturated fatty acids, organism-specific biosystem; Fatty acid elongation, organism-specific biosystem
• Function: acyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activity

Q&As

What are the potential medical applications of ACOT2 protein?

ACOT2 protein may have therapeutic implications for the treatment of metabolic disorders such as obesity and diabetes, as well as certain types of cancer. It may also be a target for drug development to enhance fatty acid oxidation.

Can ACOT2 protein be used in diagnostic tests or assays?

ACOT2 protein may be used as a diagnostic biomarker for metabolic disorders or cancer, but more research is needed to establish its clinical utility.

What are some challenges or limitations to using ACOT2 protein in medicine or biotechnology?

One of the challenges is the lack of specificity of current inhibitors and modulators of ACOT2 activity. Additionally, more research is needed to fully understand the role of ACOT2 in various diseases and to validate its potential as a therapeutic target.

Can ACOT2 protein be used in diagnostic tests?

ACOT2 protein is not commonly used in diagnostic tests, but changes in its expression or activity may serve as biomarkers for certain diseases or conditions.

What techniques are used to study ACOT2 protein and its function?

Common techniques used to study ACOT2 protein and its function include molecular biology and biochemistry techniques such as gene expression analysis, enzyme assays, and protein purification. Imaging techniques such as fluorescent microscopy may also be used to visualize ACOT2 localization and function within cells.

How might ACOT2 protein be used in personalized medicine?

ACOT2 protein expression levels may have the potential to identify individuals who would benefit from specific treatments for metabolic disorders or cancer, allowing for personalized treatment plans.

Are there any drugs or compounds that target or modulate ACOT2 protein activity?

There are currently no FDA-approved drugs that target ACOT2 protein activity, but researchers are investigating potential inhibitors and modulators of ACOT2 as therapeutic agents for metabolic disorders and cancer.

What are some potential applications for ACOT2 protein in biotechnology or medicine?

ACOT2 protein has potential applications in drug development for metabolic disorders and obesity. It also has applications in research as a biomarker for poor prognosis in cancer patients and as a therapeutic target for cancer treatment.

Are there any known mutations or variations in the ACOT2 gene that are linked to disease?

There have been some studies that suggest variations in the ACOT2 gene may be associated with increased risk for obesity and metabolic disorders. However, more research is needed to establish these links definitively.

What research areas are exploring the potential of ACOT2 protein?

Research areas exploring the potential of ACOT2 protein include metabolic disorders such as diabetes and obesity, as well as cancer research and drug development.

What are some potential future directions for research on ACOT2 protein?

There is ongoing research to further understand ACOT2's role in lipid metabolism and its potential therapeutic targets in diseases such as obesity and cancer. Additionally, there is interest in developing more specific and effective inhibitors or modulators of ACOT2 activity for potential therapeutic use.

What challenges exist in targeting ACOT2 protein for drug development?

One challenge is understanding the complex role of ACOT2 in lipid metabolism and its potential off-target effects on other metabolic pathways. Developing selective ACOT2 inhibitors or modulators with good pharmacokinetic properties is also a challenge.

How is ACOT2 protein regulated in the body?

ACOT2 protein expression and activity are regulated by a variety of factors, including hormones, nutrient availability, and cellular energy status. Other enzymes and proteins involved in lipid metabolism may also impact ACOT2 activity.