Recombinant Rat ALT, His-tagged
Cat.No. : | ALT-3248R |
Product Overview : | Alanine Aminotransferase (ALT) |
- Specification
- Gene Information
- Related Products
Description : | human homolog is a cytosolic alanine aminotransferase . |
Source : | E. Coli |
Species : | Rat |
Tag : | His |
Form : | Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
Molecular Mass : | 56.6kDa |
Protein length : | 496 |
Endotoxin : | <1.0eu per 1ug (determined by the lal</1.0eu |
Purity : | >95% |
Applications : | SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP) |
Notes : | Small volumes of ALT recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | Gpt glutamic-pyruvate transaminase (alanine aminotransferase) [ Rattus norvegicus ] |
Official Symbol : | Gpt |
Synonyms : | Gpt1; alanine aminotransferase 1; ALT1; GPT 1; glutamic pyruvate transaminase; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1; glutamate pyruvate transaminase 1; glutamic pyruvic transaminase 1, soluble; glutamic pyruvic transaminase (alanine aminotrasferase) |
Gene ID : | 81670 |
mRNA Refseq : | NM_031039 |
Protein Refseq : | NP_112301 |
UniProt ID : | P25409 |
Chromosome Location : | 7q34 |
Pathway : | 2-Oxocarboxylic acid metabolism, organism-specific biosystem; Amino acid synthesis and interconversion (transamination), organism-specific biosystem |
Function : | L-alanine:2-oxoglutarate aminotransferase activity; pyridoxal phosphate binding |
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◆ Native Protein | ||
GPT-188S | Active Native Swine Glutamate Pyruvate Transaminase | +Inquiry |
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◆ Lysates | ||
GPT-721RCL | Recombinant Rat GPT cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (5)
Ask a questionThe GPT gene, encompassing GPT1 and GPT2, is pivotal in glucose and amino acid metabolism. GPT2 is notably linked to tumorigenesis in various cancers, while the involvement of GPT1 in cancer remains uncertain and requires further exploration.
The GPT gene encodes ALT1, a key enzyme in cellular metabolism. ALT1 facilitates the reversible transamination between alanine and 2-oxoglutarate, crucial for glucose and amino acid metabolism. Elevated serum ALT1 levels are commonly used as a biomarker for liver injury caused by drug toxicity, infection, alcohol, and steatosis.
SMS protein alone doesn't impact LSCC patient prognosis, but when combined with GPT, it shows significance. Inconsistency between SMS transcriptional and protein levels may stem from various factors, including the involvement of regulatory elements and different post-transcriptional and post-translational modifications.
Analysis of LSCC tissues and cell lines revealed an inverse relationship between GPT and SMS expressions, confirmed through qRT-PCR and TCGA data. GPT protein, primarily located in the epithelium, was down-regulated in LSCC tissues.
GPT gene expression serves as a marker for cancer-induced metabolic reprogramming in tissues, indicating shifts in energy metabolism and biosynthetic processes.
Customer Reviews (3)
Write a reviewFantastic customer support. They genuinely care about the success of our research.
Top-notch protein quality! It's our go-to for reliable and reproducible results.
Very happy with this lab product!
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