Recombinant Human ADH4, His-tagged
Cat.No. : | ADH4-3252H |
Product Overview : | Alcohol dehydrogenase 4 (ADH4) |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. |
Source : | E. Coli or Yeast |
Species : | Human |
Tag : | His |
Form : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Protein length : | 380 |
Purity : | >90% |
Notes : | Small volumes of ADH4 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. For extended storage, store at -20 or -80 degree C. |
Storage Buffer : | PBS pH 7.4, 50% glycerol |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide [ Homo sapiens ] |
Official Symbol : | ADH4 |
Synonyms : | ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide; alcohol dehydrogenase 4; ADH 2; aldehyde reductase; alcohol dehydrogenase class II pi chain; ADH-2; |
Gene ID : | 127 |
mRNA Refseq : | NM_000670 |
Protein Refseq : | NP_000661 |
MIM : | 103740 |
UniProt ID : | P08319 |
Chromosome Location : | 4q22 |
Pathway : | Biological oxidations, organism-specific biosystem; Drug metabolism - cytochrome P450, organism-specific biosystem; Drug metabolism - cytochrome P450, conserved biosystem; Ethanol oxidation, organism-specific biosystem; Fatty Acid Omega Oxidation, organis |
Function : | NAD binding; NADPH:quinone reductase activity; alcohol dehydrogenase (NAD) activity; alcohol dehydrogenase activity, zinc-dependent; alditol:NADP+ 1-oxidoreductase activity; all-trans retinal binding; benzaldehyde dehydrogenase activity; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; retinol binding; retinol dehydrogenase activity; zinc ion binding; |
Products Types
◆ Lysates | ||
ADH4-29HCL | Recombinant Human ADH4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (10)
Ask a questionADH4 may have implications in the metabolism of other endogenous compounds or xenobiotics, suggesting its involvement in broader physiological functions.
Genetic variations or polymorphisms in the ADH4 gene may impact alcohol metabolism and susceptibility to alcohol-related disorders, emphasizing the role of genetic factors in its function.
ADH4 exhibits a tissue-specific expression pattern, and its expression is regulated by various factors such as transcriptional control and signaling pathways.
The enzymatic kinetics and catalytic properties of ADH4 contribute to its overall activity and efficiency in alcohol metabolism.
Exploring the consequences of ADH4 deficiency or overexpression provides insights into its role in alcohol metabolism and its impact on physiological processes.
ADH4 can efficiently metabolize different alcohol substrates, and its substrate specificity may differ from other ADH enzymes.
ADH4 expression and activity can be influenced by chronic alcohol exposure or withdrawal, and studying the underlying molecular mechanisms can shed light on alcohol-related effects.
Interacting proteins or cofactors can modulate the activity or function of ADH4, and investigating the molecular mechanisms involved can enhance our understanding of its regulation.
The activity or function of ADH4 can potentially be modulated by pharmacological agents or environmental factors, presenting potential therapeutic implications.
The structural features of ADH4 play a crucial role in its catalytic activity and binding affinity for alcohol, and understanding these features provides insights into its function.
Customer Reviews (2)
Write a reviewShows exceptional specificity in binding to DNA or RNA in nucleic acid binding assays.
Provides accurate and reliable quantification of protein isoforms in proteoforms analysis.
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