Recombinant Mouse Interleukin 20
Cat.No. : | Il20-74M |
Product Overview : | Recombinant Mouse Interleukin-20 produced inE.Coliis a single, non-glycosylated polypeptide chain containing 152 amino acids and having a total molecular mass of 17,584 Dalton. The IL-20 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
- Download
Cat. No. : | Il20-74M |
Description : | IL20 is a cytokine structurally related to interleukin 10 (IL10). IL20 cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. |
Source : | Escherichia Coli. |
Amino Acid Sequence : | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Lys-Thr-Leu. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : | Lyophilized from a concentrated (1 mg/ml) solution containing no additives. |
Solubility : | It is recommended to reconstitute the lyophilized Interleukin-20 in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
Specific Activity : | The biological activity was determined by measuring the dose dependent activation of STAT3 in human epidermal keratinocytes (HEK2a cells). Significant STAT3 activation is observed with >100 ng/mL of Interleukin-20 recombinant mouse. |
Protein Content : | Protein quantitation was carried out by two independent methods: 1. UV spectroscopy at 280 nm using the absorbency value of 0.552 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of IL-20 as a Reference Standard. |
Stability : | Lyophilized Interleukin-20 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL20 should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | Il20 interleukin 20 [ Mus musculus ] |
Synonyms : | Il20; interleukin 20; Zcyto10; MGC130536; four helix bundle cytokine 10 |
Gene ID : | 58181 |
mRNA Refseq : | NM_021380 |
Protein Refseq : | NP_067355 |
UniProt ID : | Q9JKV9 |
Chromosome Location : | 1 E4 |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway |
Function : | cytokine activity; interleukin-20 receptor binding; receptor binding |
Products Types
◆ Recombinant Protein | ||
Il20-1029M | Recombinant Mouse Il20 Protein, His-tagged | +Inquiry |
IL20-240H | Active Recombinant Human IL20 Protein (Leu25-Glu176), C-His tagged, Animal-free, Carrier-free | +Inquiry |
Il20-3509M | Active Recombinant Mouse Il20 Protein | +Inquiry |
IL20-1818M | Recombinant Mouse IL20 Protein | +Inquiry |
IL20-172H | Recombinant Active Human IL20 Protein, His-tagged(C-ter) | +Inquiry |
◆ Lysates | ||
IL20-5233HCL | Recombinant Human IL20 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionIL-20 has been implicated in tissue repair processes, and harnessing its properties may have implications for regenerative medicine.
IL-20 is being explored as a potential therapeutic target in autoimmune diseases due to its involvement in immune system regulation.
IL-20 is known to promote inflammation, and understanding its mechanisms may lead to targeted anti-inflammatory therapies.
Yes, there are several clinical trials exploring the safety and efficacy of IL-20 inhibitors in various disease contexts.
Tailoring treatments based on individual IL-20 levels and responses is a potential avenue for personalized medicine.
Customer Reviews (3)
Write a reviewThe reliability and reproducibility of the IL20 Protein's performance make it a go-to option for WB experiments.
The IL20 protein is of exceptional quality and will undoubtedly meet my experimental needs with utmost reliability and accuracy.
By utilizing the IL20 protein in my experiments, I can trust that I am working with a product of the highest caliber, backed by a company dedicated to delivering exceptional quality and support.
Ask a Question for All Il20 Products
Required fields are marked with *
My Review for All Il20 Products
Required fields are marked with *
Inquiry Basket