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Native Human ApoB

Cat.No.: ApoB-3556H
Description: Purified native Human ApoB proteinApolipoprotein B is the dominant protein constituent of LDL. The concentration of Apo B in normal plasma is 90 mg per 100 ml. Apo B is thought to stabilize lipid emulsions, serve as a cofactor and modulator of enzymatic reactions, manage export of lipids out of cells and direct lipids to target organs. Apo B levels are positively correlated with the risk of coronary disease. Apo B levels may be a more sensitive predictor of cardiovascular risk than LDL levels and do not involve fasting for accurate measurement. Two forms of Apo B exist: Apo B-100 and Apo B-48. The first is found in VLDL and LDL and is produced by the liver. The second is found in chylomicrons and originates in the intestine..
Source: Human plasma
Species: Human
Form: Essentially free of other plasma lipoproteins as determined by electrophoresis using Fat Red 7B stain for lipids and Coomassie Blue for proteins.
Molecular Mass: 550 kDa
Purity: >95% pure by SDS-PAGE.
Notes: Small volumes of ApoB native protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage: Store at 2-4 deg C. Do not freeze.
Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name: APOB apolipoprotein B (including Ag(x) antigen) [ Homo sapiens ]
Official Symbol: APOB
Synonyms: APOB; apolipoprotein B (including Ag(x) antigen); apolipoprotein B-100; apoB-48; apoB-100; apo B-100; mutant Apo B 100; apolipoprotein B48; FLDB; LDLCQ4;
Gene ID: 338
mRNA Refseq: NM_000384
Protein Refseq: NP_000375
UniProt ID: P04114
Chromosome Location: 2p24-p23
Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Chylomicron-mediated lipid transport, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; Fat digestion and absorption, organism-specific biosystem; Fat digestion and absorption, conserved biosystem; Hemostasis, organism-specific biosystem; LDL-mediated lipid transport, organism-specific biosystem;
Function: cholesterol transporter activity; enzyme binding; heparin binding; lipid transporter activity; low-density lipoprotein particle receptor binding; phospholipid binding; protein heterodimerization activity;

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