"ApoE2" Related Products

Recombinant Human ApoE2

Cat.No.: ApoE2-3561H
Product Overview: ApoE2
Description: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Source: E. Coli
Species: Human
Form: Lyophilized
Molecular Mass: 36,154 Da
Protein length: 317
Purity: >90% by SDS-PAGE & HPLC analyses
Notes: Small volumes of ApoE2 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name: ApoE2
Official Symbol: ApoE2
Synonyms: APOE; APOE; AD2; LPG; LDLCQ5; Apo-E;
Gene ID: 348
mRNA Refseq: NM_000041.2
Protein Refseq: NP_000032.1
MIM: 104310
UniProt ID: P02649
Chromosome Location: Chromosome: 19; NC_000019.10 (44905782..44909393). Location: 19q13.2
Function: ?ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants

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