Recombinant Human ApoE3 ApoE3-3562H

Recombinant Human ApoE3

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Recombinant Human ApoE3

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Cat.No. : ApoE3-3562H
Product Overview : ApoE3
Description : Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Source : E. Coli
Species : Human
Form : Lyophilized
Molecular Mass : 36,154 Da
Protein length : 317
Purity : >90% by SDS-PAGE & HPLC analyses
Notes : Small volumes of ApoE3 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : ApoE3
Official Symbol : ApoE3
Synonyms : APOE; APOE; AD2; LPG; LDLCQ5; Apo-E;
Gene ID : 348
mRNA Refseq : NM_000041.2
Protein Refseq : NP_000032.1
MIM : 104310
UniProt ID : P02649
Chromosome Location : Chromosome: 19; NC_000019.10 (44905782..44909393). Location: 19q13.2
Function : ?ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants

Related Gene

APOE

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