Recombinant Human DOT1L, GST-tagged DOT1L-658H

Recombinant Human DOT1L, GST-tagged

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Recombinant Human DOT1L, GST-tagged

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Cat.No. : DOT1L-658H
Product Overview : Recombinant human DOT1 protein, catalytic domain (DOT1L, KMT4, accession Q8TEK3, amino acids 1-472), containing an N-terminal GST tag, expressed in E. coli
Description : The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.
Source : E. coli
Species : Human
Tag : GST
Form : Recombinant GST-DOT1L (1 µg/µl) 100 mM Tris pH 8.0, 5 mM glutathione and 25% glycerol.
Molecular Mass : 85 kDa
Purity : 70% as measured by gel densitometry.
Applications : Recombinant DOT1L Catalytic Domain, human is useful for histone H3 methylation experiments, enzyme kinetics and inhibitor screening. Use of 3-5 µg DOT1L per reaction with HeLa or recombinant nucleosomes as a substrate is recommended.
Storage : Stable for six months at -80°C from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.
Gene Name : DOT1L DOT1-like histone H3K79 methyltransferase [ Homo sapiens (human) ]
Official Symbol : DOT1L
Synonyms : DOT1L; DOT1; KMT4; DOT1-like histone H3K79 methyltransferase; histone-lysine N-methyltransferase, H3 lysine-79 specific; H3-K79-HMTase; DOT1-like protein; lysine N-methyltransferase 4; histone methyltransferase DOT1L; histone H3-K79 methyltransferase; DOT1-like, histone H3 methyltransferase; NP_115871.1; EC 2.1.1.43
Gene ID : 84444
mRNA Refseq : NM_032482
Protein Refseq : NP_115871
MIM : 607375
UniProt ID : Q8TEK3
Chromosome Location : 19p13.3
Pathway : Lysine degradation; Transcriptional misregulation in cancer
Function : DNA binding; histone-lysine N-methyltransferase activity; protein binding

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