Recombinant Chicken IL-1 Receptor Antagonist

• Cat.No.: IL1ra-45C
• Product Overview: Chicken IL-1 Receptor Antagonist was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.

Specification

• Description: The IL-1 family of cytokines encompasses eleven proteins that each share a similar β-barrel structure and bind to Ig-like receptors. Several of the well characterized members of the IL-1-like cytokines play key roles in the development and regulation of inflammation. IL-1α (IL-1F1), IL-1β (IL-1F2), and IL-18 (IL-1F4) are well-known inflammatory cytokines active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. In contrast, IL-1 receptor antagonist (IL-1ra; IL-1F3) and IL-36 receptor antagonist (IL-36ra; IL-1F5) reduce inflammation by blocking the binding of the agonist receptor ligands. IL-33 (IL-1F11) is thought to function as an "alarmin" released following cell necrosis to alerting the immune system to tissue damage or stress. The biological properties of IL-37 (IL-1F7) are mainly those of down-regulating inflammation.
• Source: Yeast
• Species: Chicken
• Form: Lyophilized
• Molecular Mass: 17.8 kDa
• AA Sequence: SVPCRAPALQ TKVFKYRIWD MNQQSLYLRD DQLVAGHLQG ANAALEEKVF WVPNRFFKHE LQPVIMGIRN GTRCLACPAA PQPTLQLQDA DITELPRSGA ASAPFTFFRT YKDGLWRFES AANPGWFLCT SARAHQPLGL SRRPDAAHVL DFYFQLC (157)
• Applications: The Chicken IL-1 Receptor Antagonist protein can be used in cell culture, as an IL-1RA ELISA Standard, and as a Western Blot Control.
• Storage: -20 C