"TIMP3" Related Products

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Recombinant Human TIMP3, MIgG2a Fc-tagged

Cat.No.: TIMP3-001H
Product Overview: The extracellular domain of human TIMP3(AAH14277.1)(Cys24-Pro211) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.
Description: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrixmetalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expressionof this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein islocalized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby"sfundus dystrophy.
Source: CHO cell
Species: Human
Tag: MIgG2a Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its ability to induce alkaline phosphatase production .
Molecular Mass: 48KDa (monomer)
AA Sequence: Cys24-Pro211
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: TIMP3 TIMP metallopeptidase inhibitor 3 [ Homo sapiens ]
Official Symbol: TIMP3
Synonyms: TIMP3; TIMP metallopeptidase inhibitor 3; SFD, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); metalloproteinase inhibitor 3; TIMP-3; MIG-5 protein; protein MIG-5; tissue inhibitor of metalloproteinases 3; SFD; K222; K222TA2; HSMRK222;
Gene ID: 7078
mRNA Refseq: NM_000362
Protein Refseq: NP_000353
MIM: 188826
UniProt ID: P35625
Chromosome Location: 22q12.3
Pathway: Endochondral Ossification, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem;
Function: enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity; protein binding;

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