Recombinant Human CCL11, HIgG1 Fc-tagged, mutant

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Recombinant Human CCL11, HIgG1 Fc-tagged, mutant

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Cat.No. : CCL11-166H
Product Overview : The extracellular domain of human CCL11 (NP_002977.1)(Gly24-Pro97) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell.
Description : This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
Source : CHO cell
Species : Human
Tag : HIgG1 Fc-tagged, mutant
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to chemoattract BaF3 mouse pro-B cells.
Molecular Mass : 34KDa (monomer)
AA Sequence : Gly24-Pro9 7
Endotoxin : <0.06 eu/μg as determined by lal>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : CCL11 chemokine (C-C motif) ligand 11 [ Homo sapiens ]
Official Symbol : CCL11
Synonyms : CCL11; chemokine (C-C motif) ligand 11; SCYA11, small inducible cytokine subfamily A (Cys Cys), member 11 (eotaxin); eotaxin; eotaxin 1; MGC22554; eotaxin-1; C-C motif chemokine 11; small-inducible cytokine A11; eosinophil chemotactic protein; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); SCYA11;
Gene ID : 6356
mRNA Refseq : NM_002986
Protein Refseq : NP_002977
MIM : 601156
UniProt ID : P51671
Chromosome Location : 17q21.1-q21.2
Pathway : Asthma, organism-specific biosystem; Asthma, conserved biosystem; CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem;
Function : chemokine activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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