"HAVCR2" Related Products

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Recombinant Human HAVCR2, MIgG2a Fc-tagged

Cat.No.: HAVCR2-217H
Product Overview: The extracellular domain of human Tim-3 (NP_116171.3) (Ser22-Arg200) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO celL
Description: The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins.CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokinesecretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-typehypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infectionsand the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein thatregulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotesimmunological tolerance.
Source: CHO cells
Species: Human
Tag: MIgG2a Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its binding ability in a functional ELISA.
Molecular Mass: 48 KDa (monomer)
AA Sequence: Ser22-Arg200
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: HAVCR2 hepatitis A virus cellular receptor 2 [ Homo sapiens ]
Official Symbol: HAVCR2
Synonyms: HAVCR2; hepatitis A virus cellular receptor 2; FLJ14428; Tim 3; TIM3; TIMD3; kidney injury molecule-3; T-cell membrane protein 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; KIM-3; Tim-3; TIMD-3; HAVcr-2;
Gene ID: 84868
mRNA Refseq: NM_032782
Protein Refseq: NP_116171
MIM: 606652
UniProt ID: Q8TDQ0
Chromosome Location: 5q34

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