Recombinant Human CD274, MIgG2a Fc-tagged CD274-002H

Recombinant Human CD274, MIgG2a Fc-tagged

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Recombinant Human CD274, MIgG2a Fc-tagged

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Cat.No. : CD274-002H
Product Overview : The extracellular domain of human PDL1 (NP_054862.1) ( Phe19-Arg238) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell
Description : CD274 (CD274 molecule) is a protein-coding gene. Diseases associated with CD274 include pulmonary venoocclusive disease, and htlv-1 associated myelopathy/tropical spastic paraparesis, and among its related super-pathways are Immune System and Phosphorylation of CD3 and TCR zeta chains. GO annotations related to this gene include protein binding
Source : CHO cells
Species : Human
Tag : MIgG2a Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to inhibit anti-CD3 antibody induced IL-2 secretion in human T lymphocytes.
Molecular Mass : 54 KDa (monomer)
AA Sequence : Phe19-Arg238
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : CD274 CD274 molecule [ Homo sapiens ]
Official Symbol : CD274
Synonyms : CD274; CD274 molecule; CD274 antigen , PDCD1LG1, programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; B7 homolog 1; B7 H; B7 H1; B7H1; PD L1; PDL1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1; B7-H; PD-L1; PDCD1L1; PDCD1LG1; MGC142294; MGC142296;
Gene ID : 29126
mRNA Refseq : NM_014143
Protein Refseq : NP_054862
MIM : 605402
UniProt ID : Q9NZQ7
Chromosome Location : 9p24.1
Pathway : Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem;
Function : protein binding; protein tyrosine phosphatase activity; receptor activity;

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