Recombinant Human CD80, HIgG1 Fc-tagged CD80-617H

Recombinant Human CD80, HIgG1 Fc-tagged

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Recombinant Human CD80, HIgG1 Fc-tagged

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Cat.No. : CD80-617H
Product Overview : The extracellular domain of human CD80 [B7-1] (NP_005182.1) (Val35-Asn242) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
Description : The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. Theactivated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor foradenovirus subgroup B and may play a role in lupus neuropathy
Source : CHO cells
Species : Human
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to induce IL-2 secretion by Jurkat human acute T cell leukemia cells.
Molecular Mass : 50 KDa (monomer)
AA Sequence : Val35-Asn242
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : CD80 CD80 molecule [ Homo sapiens ]
Official Symbol : CD80
Synonyms : CD80; CD80 molecule; CD28LG, CD28LG1, CD80 antigen (CD28 antigen ligand 1, B7 1 antigen) , CD80 molecule; T-lymphocyte activation antigen CD80; B lymphocyte activation antigen B7; B7 1; B7.1; activation B7-1 antigen; costimulatory factor CD80; CTLA-4 counter-receptor B7.1; B-lymphocyte activation antigen B7; costimulatory molecule variant IgV-CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); B7; BB1; B7-1; LAB7; CD28LG; CD28LG1;
Gene ID : 941
mRNA Refseq : NM_005191
Protein Refseq : NP_005182
MIM : 112203
UniProt ID : P33681
Chromosome Location : 3q13.3-q21
Pathway : Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem;
Function : coreceptor activity; protein binding; receptor activity;

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