Recombinant Human CD274, HIgG1 Fc-tagged

Cat.No.: CD274-020H
Product Overview: The extracellular domain of human PDL1 (NP_054862.1) ( Phe19-Arg238) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
Description: CD274 (CD274 molecule) is a protein-coding gene. Diseases associated with CD274 include pulmonary venoocclusive disease, and htlv-1 associated myelopathy/tropical spastic paraparesis, and among its related super-pathways are Immune System and Phosphorylation of CD3 and TCR zeta chains. GO annotations related to this gene include protein binding
Source: CHO cells
Species: Human
Tag: HIgG1 Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its ability to inhibit anti-CD3 antibody induced IL-2 secretion in human T lymphocytes.
Molecular Mass: 54 KDa (monomer)
AA Sequence: Phe19-Arg238
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: CD274 CD274 molecule [ Homo sapiens ]
Official Symbol: CD274
Synonyms: CD274; CD274 molecule; CD274 antigen , PDCD1LG1, programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; B7 homolog 1; B7 H; B7 H1; B7H1; PD L1; PDL1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1; B7-H; PD-L1; PDCD1L1; PDCD1LG1; MGC142294; MGC142296;
Gene ID: 29126
mRNA Refseq: NM_014143
Protein Refseq: NP_054862
MIM: 605402
UniProt ID: Q9NZQ7
Chromosome Location: 9p24.1
Pathway: Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem;
Function: protein binding; protein tyrosine phosphatase activity; receptor activity;

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