Recombinant Human CYP2C9 2 (R144C) CYP2C9-544H

Recombinant Human CYP2C9 2 (R144C)

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Recombinant Human CYP2C9 2 (R144C)

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Cat.No. : CYP2C9-544H
Product Overview : Recombinant Human Cytochrome P450 2C9*2 (R144C) was expressed in E. coli.
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Source : E. coli
Species : Human
Bio-activity : 12-88 units/mg protein
Molecular Mass : mol wt 54370 g/mol
Unit Definition : One unit will convert 1.0 nanomole of diclofenac (2-(2,6-dichloranilino) phenylacetic acid) 4`-hydroxylated product per minute at pH 7.4 at 37 °C.
Storage : ?70°C
Concentration : 3.5-25 mg protein/mL (protein)50-150 nmol/mL (P450)6-14 nmol/mg protein (specific content)
Gene Name : CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 [ Homo sapiens (human) ]
Official Symbol : CYP2C9
Synonyms : CYP2C9; CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9; cytochrome P450, family 2, subfamily C, polypeptide 9; cytochrome P450 2C9; cytochrome P-450MP; cytochrome P450 PB-1; microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P-450 S-mephenytoin 4-hydroxylase; NP_000762.2; EC 1.14.13.48; EC 1.14.13.49; EC 1.14.13.80
Gene ID : 1559
mRNA Refseq : NM_000771
Protein Refseq : ?NP_000762
MIM : 601130
UniProt ID : P11712
Chromosome Location : 10q24
Pathway : Arachidonate Epoxygenase / Epoxide Hydrolase; Arachidonic acid metabolism; Drug metabolism - cytochrome P450
Function : (R)-limonene 6-monooxygenase activity; drug binding; heme binding

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