Recombinant Human CYP3A4 CYP3A4-549H

Recombinant Human CYP3A4


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Recombinant Human CYP3A4

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Cat.No. : CYP3A4-549H
Product Overview : Recombinant Human CYP3A4 was expressed in Saccharomyces cerevisiae.
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Source : Saccharomyces cerevisiae
Species : Human
Form : 50 mM Tris (pH 7.4), 1 mM EDTA, 20% glycerol
Bio-activity : activity: ≥10 units/pmol enzymesecondary activity: ≥20 units/mg protein (Reductase activity)
Unit Definition : P450 Activity: One unit will oxidize 1 picomole of testosterone per minute at pH 7.4 at 30 °C.Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.
Storage : ?70°C
Concentration : ≤60 mg/mL (Protein)≥10 pmol/mg protein (P450)
Gene Name : CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 [ Homo sapiens (human) ]
Official Symbol : CYP3A4
Synonyms : CYP3A4; HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1; cytochrome P450, family 3, subfamily A, polypeptide 4; cytochrome P450 3A4; nifedipine oxidase; cytochrome P450 3A3; cytochrome P450 HLp; cytochrome P450-PCN1; cytochrome P450 NF-25; albendazole sulfoxidase; quinine 3-monooxygenase; albendazole monooxygenase; P450-III, steroid inducible; glucocorticoid-inducible P450; 1,8-cineole 2-exo-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; NP_001189784.1; EC; EC; EC; EC; NP_059488.2
Gene ID : 1576
mRNA Refseq : NM_017460
Protein Refseq : NP_059488
MIM : 124010
UniProt ID : P08684
Chromosome Location : 7q21.1
Pathway : Aflatoxin B1 metabolism; Biological oxidations; Codeine and morphine metabolism
Function : albendazole monooxygenase activity; caffeine oxidase activity; heme binding

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