"CTSD" Related Products

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Recombinant Human CTSD, His-tagged

Cat.No.: CTSD-1649H
Product Overview: Recombinant Human CTSD (Leu21-Leu412), fused with a C-terminal 10-His tag, was expressed in Mouse NSO Cells.
Description: This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.
Source: Mouse NSO Cells
Species: Human
Tag: His
Predicted N Terminal: Leu21
Form: Supplied as a 0.2 µm filtered solution in MES and NaCl.
Bio-activity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2.
Molecular Mass: Predicted Molecular Mass: 44 kDaSDS-PAGE: 50 kDa, reducing conditions
Endotoxin: < 1.0 EU per 1 μg of the protein by the LAL method.
Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage: Avoid repeated freeze-thaw cycles.6 months from date of receipt, -20 to -70 °C as supplied.3 months, -20 to -70 °C under sterile conditions after opening.
Reconstitution: Reconstitute at 100 µg/mL in sterile, deionized water.
Gene Name: CTSD cathepsin D [ Homo sapiens (human) ]
Official Symbol: CTSD
Synonyms: CTSD; cathepsin D; CPSD; CLN10; MGC2311; cathepsin D; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; Cathepsin D; EC 3.4.23.5; OTTHUMP00000042282; OTTHUMP00000196039; OTTHUMP00000198692
Gene ID: 1509
mRNA Refseq: NM_001909
Protein Refseq: NP_001900
MIM: 116840
UniProt ID: P07339
Chromosome Location: 11p15.5
Pathway: Ceramide signaling pathway; Direct p53 effectors; LKB1 signaling events; Lysosome; Tuberculosis; thyroid hormone biosynthesis
Function: aspartic-type endopeptidase activity; peptidase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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