Recombinant Human CTSD, His-tagged

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Recombinant Human CTSD, His-tagged

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Cat.No. : CTSD-1649H
Product Overview : Recombinant Human CTSD (Leu21-Leu412), fused with a C-terminal 10-His tag, was expressed in Mouse NSO Cells.
Description : This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.
Source : Mammalian cells
Species : Human
Tag : His
Predicted N Terminal : Leu21
Form : Supplied as a 0.2 µm filtered solution in MES and NaCl.
Bio-activity : Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2.
Molecular Mass : Predicted Molecular Mass: 44 kDaSDS-PAGE: 50 kDa, reducing conditions
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles.6 months from date of receipt, -20 to -70 °C as supplied.3 months, -20 to -70 °C under sterile conditions after opening.
Reconstitution : Reconstitute at 100 µg/mL in sterile, deionized water.
Gene Name : CTSD cathepsin D [ Homo sapiens (human) ]
Official Symbol : CTSD
Synonyms : CTSD; cathepsin D; CPSD; CLN10; MGC2311; cathepsin D; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; Cathepsin D; EC 3.4.23.5; OTTHUMP00000042282; OTTHUMP00000196039; OTTHUMP00000198692
Gene ID : 1509
mRNA Refseq : NM_001909
Protein Refseq : NP_001900
MIM : 116840
UniProt ID : P07339
Chromosome Location : 11p15.5
Pathway : Ceramide signaling pathway; Direct p53 effectors; LKB1 signaling events; Lysosome; Tuberculosis; thyroid hormone biosynthesis
Function : aspartic-type endopeptidase activity; peptidase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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