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Active Recombinant Human CTSD, His-tagged

Cat.No. : CTSD-1649H
Product Overview : Recombinant Human CTSD (Leu21-Leu412), fused with a C-terminal 10-His tag, was expressed in Mouse NSO Cells.
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Description : This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.
Source : Mammalian cells
Species : Human
Tag : His
Predicted N Terminal : Leu21
Form : Supplied as a 0.2 µm filtered solution in MES and NaCl.
Bio-activity : Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2.
Molecular Mass : Predicted Molecular Mass: 44 kDaSDS-PAGE: 50 kDa, reducing conditions
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles.6 months from date of receipt, -20 to -70 °C as supplied.3 months, -20 to -70 °C under sterile conditions after opening.
Reconstitution : Reconstitute at 100 µg/mL in sterile, deionized water.
Gene Name : CTSD cathepsin D [ Homo sapiens (human) ]
Official Symbol : CTSD
Synonyms : CTSD; cathepsin D; CPSD; CLN10; MGC2311; cathepsin D; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; Cathepsin D; EC 3.4.23.5; OTTHUMP00000042282; OTTHUMP00000196039; OTTHUMP00000198692
Gene ID : 1509
mRNA Refseq : NM_001909
Protein Refseq : NP_001900
MIM : 116840
UniProt ID : P07339
Chromosome Location : 11p15.5
Pathway : Ceramide signaling pathway; Direct p53 effectors; LKB1 signaling events; Lysosome; Tuberculosis; thyroid hormone biosynthesis
Function : aspartic-type endopeptidase activity; peptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is the relationship between CTSD proteins and cognitive function? 05/02/2022

There is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.

What is the relationship between changes in CTSD protein levels and disease? 12/13/2021

In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.

For people with cognitive decline, how do you assess their CTSD protein levels? 01/19/2021

For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.

How can treatment be used to alter the level or function of the CTSD protein? 11/14/2020

It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.

Is CTSD protein involved in Parkinson's disease? 02/08/2020

People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.

In which diseases does the CTSD protein play a role? 12/11/2019

CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.

Customer Reviews (3)

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Reviews
07/12/2021

    Good at western-blot experiments.

    03/28/2021

      In experiments, the biocompatibility performed well.

      03/02/2021

        The experimental conditions are broad, and the experimental results are accurate and repeatable.

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