Recombinant Human casein kinase 2, alpha 1 polypeptide CSNK2A1-21H

Recombinant Human casein kinase 2, alpha 1 polypeptide

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Recombinant Human casein kinase 2, alpha 1 polypeptide

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Cat. No. : CSNK2A1-21H
Product Overview : Recombinant Human Casein Kinase 2 alpha is a non-glycosylated polypeptide having a molecular mass of 45.1 kDa. Casein Kinase 2 is purified by proprietary chromatographic techniques.
Description : The Casein kinase 2 (EC 2.7.11.1) is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes. Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation. A Pertussis toxin-sensitive G protein and Disheveled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2. Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm.
Source : Escherichia Coli.
Unit Definition : No protease activity detectable, specific activity > 1.320 U/mg (1U = 1µmol/min at 37 degree C) using the synthetic peptide RRRDDDSDDD.
Physical Appearance : Sterile Filtered clear solution.
Purity : Greater than 99% as determined by SDS-PAGE.
Formulation : CK2 (0.4 mg/ml) is supplied in 25mM Tris-HCl, 500mM NaCl, 1mM DTT, 500μM PMSF, 50% glycerol, pH 8.5.
Storage : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
PDB rendering based on 1jwh. :

Gene Name : CSNK2A1 casein kinase 2, alpha 1 polypeptide [ Homo sapiens ]
Synonyms : CSNK2A1; casein kinase 2, alpha 1 polypeptide; CKII; CK2A1; casein kinase II alpha 1 subunit; protein kinase CK2; CK2 catalytic subunit alpha; EC 2.7.11.1; OTTHUMP00000029925; OTTHUMP00000029926
Gene ID : 1457
mRNA Refseq : NM_001895
Protein Refseq : NP_001886
MIM : 115440
UniProt ID : P68400
Chromosome Location : 20p13
Pathway : Adherens junction; Tight junction; Wnt signaling pathway
Function : ATP binding; nucleotide binding; protein N-terminus binding; protein serine/threonine kinase activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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