Recombinant Human NCK Adaptor Protein 2


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Recombinant Human NCK Adaptor Protein 2

NCK2 Related Products

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Cat. No. : NCK2-49H
Product Overview : Recombinant Human NCK2 is produced inE.Coli.
Description : The NCK family of SH2/SH3 adaptor proteins consists of two members, NCK1 and NCK2, which couple tyrosine kinase signaling, including the EGF and PDGF receptor-pathways, to downstream signaling proteins. The NCK2 (amino acids 119-27) protein binds human PDGFR-b (Tyr-1009); over expression of NCK2 inhibits PDGF-induced membrane ruffling and lamellipod formation.
Source : Escherichia Coli.
Purity : Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Physical Appearance : Sterile Filtered clear solution.
Formulation : NCK2 protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Applications : • ELISA • Inhibition Assays • Western Blotting
Characterization : On SDS-PAGE coomassie blue stained gel, the purified recombinant protein shows a band at 45 kDa.
Storage : Store vial at -20ºC to -80ºC. When stored at the recommended temperature, this protein is stable for 12 months. Please avoid freeze-thaw cycles.
PDB rendering based on 1u5s. :

Gene Name : NCK2 NCK adaptor protein 2 [ Homo sapiens ]
Synonyms : NCK2; NCK adaptor protein 2; GRB4; NCKbeta; SH2/SH3 adaptor protein NCK-beta; noncatalytic region of tyrosine kinase, beta; Cytoplasmic protein NCK2; Nck-2
Gene ID : 8440
mRNA Refseq : NM_001004720
Protein Refseq : NP_001004720
MIM : 604930
UniProt ID : O43639
Chromosome Location : 2q12
Pathway : Axon guidance; ErbB signaling pathway; Pathogenic Escherichia coli infection-EHEC; T cell receptor signaling pathway; Axon guidance; Signaling by PDGF
Function : Function Evidence; cytoskeletal adaptor activity; protein binding; receptor signaling complex scaffold activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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