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Recombinant Human Kallikrein 1

Cat. No. : KLK1-38H
Product Overview : Recombinant Human KLK1 produced in Yeast is a single, glycosylated, polypeptide chain containing 238 amino acids and having a molecular mass of 28-32 kDa. KLK1 Human Recombinant is purified by proprietary chromatographic techniques.
Description : KLK1 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK1 is functionally conserved in its ability to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. Human Kallikrein-1, also called as Kallidinogenase, Kininogenase or Kininogenin, is an active protein enzyme present in saliva, pancreatic juices, and urine that catalyzes the proteolysis of bradykininogen to bradykinin. Kallikrein-1, which derived from human or porcine, have been used as drugs for a long time, they are mainly used in the treatment f light to medium hypertension and occlusion of cerebral and surrounding blood vessels. KLK1 demonstrates both trypsin- and chymotrypsin-like selectivities with Tyr/Arg preferred at site P1, Ser/Arg strongly preferred at P1", and Phe/Leu at P2.
Source : Pichia Pastoris
Amino Acid Sequence : The sequence of the first five N-terminal amino acids was determined and was found to be Ile-Val-Gly-Gly-Trp-Glu.
Physical Appearance : Sterile Filtered clear solution.
Purity : Greater than 98.0% as determined by both: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : The protein solution contains 1X PBS.
Biological Activity : Human Kallikrein-1 active Unit Definitin: 1 unit will hydrolize 1 μmole of H-D-Val-Leu-Arg-pNA(S-2266) per minute at pH 8.0 at 37°C Human Kallikrein-1 measured biological activity of no less than 5 Units/mg (S2266 method).
Stability : KLK1 although stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Publication :
Gene Name : KLK1 kallikrein 1 [ Homo sapiens ]
Synonyms : kallikrein serine protease 1; kallikrein 1, renal/pancreas/salivary; Klk6; KLKR; KLK1; hK1; kallikrein 1; tissue kallikrein; glandular kallikrein 1; EC 3.4.21.35; Kidney/pancreas/salivary gland kallikrein
Gene ID : 3816
mRNA Refseq : NM_002257
Protein Refseq : NP_002248
MIM : 147910
UniProt ID : P06870
Chromosome Location : 19q13.3
Function : peptidase activity; serine-type endopeptidase activity

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