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Recombinant Human ABCC10 cell lysate

Cat.No. : ABCC10-4HCL
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 [ Homo sapiens ]
Official Symbol : ABCC10
Synonyms : ABCC10; ATP-binding cassette, sub-family C (CFTR/MRP), member 10; multidrug resistance-associated protein 7; EST182763; MRP7; SIMRP7; ATP-binding cassette sub-family C member 10;
Gene ID : 89845
mRNA Refseq : NM_001198934
Protein Refseq : NP_001185863
MIM : 612509
UniProt ID : Q5T3U5
Chromosome Location : 6p12.3
Pathway : ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; ABC-family proteins mediated transport, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem;
Function : ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; nucleotide binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (14)

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Dose ABCC10 related with gefitinib resistance in non-small cell lung cancer? 04/14/2023

Yes. FTO/YTHDF2/ABCC10 axis played a role in intercellular transmission of GR cell-derived exosome-mediated gefitinib resistance both in vitro and in vivo.

Does the express of ABCC10 the same in different tumor cell? 04/14/2023

No, the expression of ABCC10 are different in different tumor. The expression of ABCC10 in adenocarcinoma is higher than that in squamous cell carcinoma.

Where dose the ABCC10 most expressed? 04/14/2023

The expression of ABCC10 was mainly located in cell membrane and cytoplasm.

Are genetic variants of ABCC10 associated with kidney tubular dysfunction? 04/14/2023

Yes, ABCC10 single-nucleotide polymorphisms (SNPs) are associated with KTD.

Can CP55 inhibit the MDR of MRP7? 04/14/2023

CP55 is not the inhibitor, but 5-cyano-6-phenylpyrimidin derivative CP55 was synthesized and found significantly reversal effect of multidrug resistance (MDR) mediated by ABCC10.

Can ABCC10 deletion prevent obesity? 04/14/2023

ABCC10 Deficiency Prevents Diet-Induced Obesity. Studies have shown that the role of ATP-binding cassette transporter C10 (ABCC10) in regulating lipid metabolism. Furthermore, deletion of ABCC10 ameliorates diet-induced obesity in mice and leads to a better response during insulin and glucose tolerance tests.

Was ABCC10 expression correlated to human breast cancer? 04/14/2023

Clinical sample analyses indicated that ABCC10 was more highly expressed in Her2+ and ER+ than in Her2-, ER-, and triple-negative breast cancer.

Do you know which cell line can be used to study MRP7/ABCC10 drug resistance? 04/14/2023

You could construct the drug-resistant stable cell by yourself. We used the paclitaxel-resistant human small cell lung cancer subline to study the resistance to paclitaxe.

Could ABCC10 transports Tenofovir(TFV)? 04/14/2023

Yes. A study concluded that TFV is a substrate for ABCC10, and genetic variability within the ABCC10 gene may influence TFV renal tubular transport and contribute to the development of KTD.

Do you know the structure of ABCC10? 04/14/2023

ABCC10 is located on the basolateral cell membrane and consists of 3 membrane-spanning domains (MSDs) and 2 nucleotide-binding domains (NBDs).

What can ABCC10 transport as a transporter? 04/14/2023

ABCC10 is a broad-specificity transporter of xenobiotics, including antitumor drugs, such as taxanes, epothilone B, vinca alkaloids, and cytarabine, as well as modulators of the estrogen pathway, such as tamoxifen.

Which inhibitors could inhibit the ABCC10 MDR function? 04/14/2023

Cepharanthine, lapatinib, erlotinib, nilotinib, imatinib, sildenafil, and vardenafil, have been reported to overcome ABCC10-mediated MDR.

Do you have full length ABCC10? 04/14/2023

Yes, you could find it on our subsite, please contact us for more information.

What's the relationship between multidrug resistance protein 7 (MRP7/ABCC10) structure and function? 04/14/2023

You can find the result in "Insights on the structure–function relationship of humanmultidrug resistance protein 7 (MRP7/ABCC10) frommolecular dynamics simulations and docking studies".

Customer Reviews (3)

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Reviews
02/07/2022

    Very good customer service

    09/06/2021

      Use well in WB

      09/02/2020

        High purity, good quality

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