Recombinant Human ABCC10 cell lysate
Cat.No. : | ABCC10-4HCL |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 [ Homo sapiens ] |
Official Symbol : | ABCC10 |
Synonyms : | ABCC10; ATP-binding cassette, sub-family C (CFTR/MRP), member 10; multidrug resistance-associated protein 7; EST182763; MRP7; SIMRP7; ATP-binding cassette sub-family C member 10; |
Gene ID : | 89845 |
mRNA Refseq : | NM_001198934 |
Protein Refseq : | NP_001185863 |
MIM : | 612509 |
UniProt ID : | Q5T3U5 |
Chromosome Location : | 6p12.3 |
Pathway : | ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; ABC-family proteins mediated transport, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem; |
Function : | ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; nucleotide binding; |
Products Types
◆ Recombinant Protein | ||
ABCC10-195M | Recombinant Mouse ABCC10 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABCC10-043H | Recombinant Human ABCC10 Protein, GST-Tagged | +Inquiry |
ABCC10-1098M | Recombinant Mouse ABCC10 Protein | +Inquiry |
ABCC10-1534H | Recombinant Human ABCC10 protein, His & T7-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (14)
Ask a questionYes. FTO/YTHDF2/ABCC10 axis played a role in intercellular transmission of GR cell-derived exosome-mediated gefitinib resistance both in vitro and in vivo.
No, the expression of ABCC10 are different in different tumor. The expression of ABCC10 in adenocarcinoma is higher than that in squamous cell carcinoma.
The expression of ABCC10 was mainly located in cell membrane and cytoplasm.
Yes, ABCC10 single-nucleotide polymorphisms (SNPs) are associated with KTD.
CP55 is not the inhibitor, but 5-cyano-6-phenylpyrimidin derivative CP55 was synthesized and found significantly reversal effect of multidrug resistance (MDR) mediated by ABCC10.
ABCC10 Deficiency Prevents Diet-Induced Obesity. Studies have shown that the role of ATP-binding cassette transporter C10 (ABCC10) in regulating lipid metabolism. Furthermore, deletion of ABCC10 ameliorates diet-induced obesity in mice and leads to a better response during insulin and glucose tolerance tests.
Clinical sample analyses indicated that ABCC10 was more highly expressed in Her2+ and ER+ than in Her2-, ER-, and triple-negative breast cancer.
You could construct the drug-resistant stable cell by yourself. We used the paclitaxel-resistant human small cell lung cancer subline to study the resistance to paclitaxe.
Yes. A study concluded that TFV is a substrate for ABCC10, and genetic variability within the ABCC10 gene may influence TFV renal tubular transport and contribute to the development of KTD.
ABCC10 is located on the basolateral cell membrane and consists of 3 membrane-spanning domains (MSDs) and 2 nucleotide-binding domains (NBDs).
ABCC10 is a broad-specificity transporter of xenobiotics, including antitumor drugs, such as taxanes, epothilone B, vinca alkaloids, and cytarabine, as well as modulators of the estrogen pathway, such as tamoxifen.
Cepharanthine, lapatinib, erlotinib, nilotinib, imatinib, sildenafil, and vardenafil, have been reported to overcome ABCC10-mediated MDR.
Yes, you could find it on our subsite, please contact us for more information.
You can find the result in "Insights on the structure–function relationship of humanmultidrug resistance protein 7 (MRP7/ABCC10) frommolecular dynamics simulations and docking studies".
Customer Reviews (3)
Write a reviewVery good customer service
Use well in WB
High purity, good quality
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