Recombinant Human AKR1C3 cell lysate
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Cat.No. : | AKR1C3-49HCL |
Description : | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) [ Homo sapiens ] |
Official Symbol : | AKR1C3 |
Synonyms : | AKR1C3; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); HSD17B5, hydroxysteroid (17 beta) dehydrogenase 5; aldo-keto reductase family 1 member C3; DDX; dihydrodiol dehydrogenase X; HAKRB; KIAA0119; PGFS; prostaglandin F synthase; indanol dehydrogenase; 3-alpha-HSD type II, brain; dihydrodiol dehydrogenase 3; chlordecone reductase homolog HAKRb; testosterone 17-beta-dehydrogenase 5; type IIb 3-alpha hydroxysteroid dehydrogenase; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; DD3; HAKRe; HA1753; HSD17B5; hluPGFS; |
Gene ID : | 8644 |
mRNA Refseq : | NM_001253909 |
Protein Refseq : | NP_001240838 |
MIM : | 603966 |
UniProt ID : | P42330 |
Chromosome Location : | 10p15-p14 |
Pathway : | Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P450, conserved biosystem; Steroid hormone biosynthesis, organism-specific biosystem; Steroid hormone biosynthesis, conserved biosystem; androgen biosynthesis, organism-specific biosystem; |
Function : | 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity; alditol:NADP+ 1-oxidoreductase activity; aldo-keto reductase (NADP) activity; androsterone dehydrogenase (A-specific) activity; androsterone dehydrogenase activity; delta4-3-oxosteroid 5beta-reductase activity; dihydrotestosterone 17-beta-dehydrogenase activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; ketoreductase activity; ketosteroid monooxygenase activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; phenanthrene 9,10-monooxygenase activity; prostaglandin F receptor activity; prostaglandin-F synthase activity; retinal dehydrogenase activity; retinol dehydrogenase activity; testosterone 17-beta-dehydrogenase (NAD+) activity; testosterone 17-beta-dehydrogenase (NADP+) activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; |
◆ Recombinant Protein
AKR1C3-090H | Recombinant Human AKR1C3 Protein, His-tagged | +Inquiry |
AKR1C3-01H | Recombinant Human AKR1C3 Protein | +Inquiry |
AKR1C3-50H | Recombinant Human AKR1C3 Protein, His-tagged | +Inquiry |
AKR1C3-600R | Recombinant Rat AKR1C3 Protein | +Inquiry |
AKR1C3-413H | Recombinant Human AKR1C3 Protein, GST-tagged | +Inquiry |
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AKR1A1 AKR1B1 AKR1B10 AKR1C1 AKR1C3 AKR1D1 AKR7A2 AKR7A3 AKR1C4 AKR1C2 AKR1E2 Akr1b3 Akr1b7 Akr1b8 Akr1c12 Akr1c12l1 Akr1c13 Akr1c14 Akr1c18 Akr1c19 Akr1c20 Akr1c21 Akr1c6 Akr1cl Akr1e1 Akr7a5 AKR1B15
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