Recombinant Human APAF1 cell lysate
Cat.No. : | APAF1-89HCL |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | APAF1 apoptotic peptidase activating factor 1 [ Homo sapiens ] |
Official Symbol : | APAF1 |
Synonyms : | APAF1; apoptotic peptidase activating factor 1; apoptotic peptidase activating factor , apoptotic protease activating factor; apoptotic protease-activating factor 1; APAF 1; CED4; APAF-1; DKFZp781B1145; |
Gene ID : | 317 |
mRNA Refseq : | NM_001160 |
Protein Refseq : | NP_001151 |
MIM : | 602233 |
UniProt ID : | O14727 |
Chromosome Location : | 12q23 |
Pathway : | Activation of caspases through apoptosome-mediated cleavage, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; |
Function : | ADP binding; ATP binding; cysteine-type endopeptidase activator activity involved in apoptotic process; nucleotide binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
APAF1-362R | Recombinant Rat APAF1 Protein, His (Fc)-Avi-tagged | +Inquiry |
APAF1-0784H | Recombinant Human APAF1 Protein (M1-S97), His tagged | +Inquiry |
APAF1-1329H | Recombinant Human APAF1 Protein (104-415 aa), His-tagged | +Inquiry |
APAF1-612M | Recombinant Mouse APAF1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Apaf1-197R | Recombinant Rat Apaf1 Protein, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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