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Recombinant Human APOL4 cell lysate

Cat.No. : APOL4-99HCL
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : APOL4 apolipoprotein L, 4 [ Homo sapiens ]
Official Symbol : APOL4
Synonyms : APOL4; apolipoprotein L, 4; apolipoprotein L4; APOLIV; apolipoprotein L-IV; APOL-IV;
Gene ID : 80832
mRNA Refseq : NM_030643
Protein Refseq : NP_085146
MIM : 607254
UniProt ID : Q9BPW4
Chromosome Location : 22q11.2-q13.2
Function : lipid binding; molecular_function;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (21)

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Does APOL4 have any known functions or biological roles? 01/13/2023

The exact functions and biological roles of APOL4 are still not well understood. However, some studies have suggested potential roles for APOL4 in cellular processes such as cell migration, intracellular trafficking, and autophagy. APOL4 has also been implicated in the innate immune response and has been shown to interact with certain pathogens, though the specific mechanisms and significance of these interactions are still being investigated.

Are there any known functional studies on APOL4? 01/10/2023

Research on APOL4 function is still emerging, and further studies are required to elucidate its specific roles. However, some studies have investigated the expression patterns and cellular localization of APOL4, providing initial insights into its potential functions.

Are there any known interactions between APOL4 and other proteins? 10/05/2022

Limited information is available regarding specific protein-protein interactions involving APOL4. However, some studies have reported potential interactions between APOL4 and proteins involved in cellular processes such as autophagy and intracellular trafficking. Additional research is necessary to clarify the interactions and functional consequences of APOL4 with other proteins.

Is APOL4 involved in lipid metabolism? 07/26/2022

There is limited research on the role of APOL4 in lipid metabolism. However, studies have shown that other members of the APOL family are involved in lipid transport and metabolism. Further investigations are needed to determine the specific contribution of APOL4 in this process.

Where is APOL4 primarily expressed in the body? 07/12/2021

APOL4 is predominantly expressed in the liver and also found in other tissues such as the kidney, skeletal muscle, and pancreas.

Is there any evidence of genetic variants or mutations in APOL4? 01/04/2021

Yes, several genetic variants and mutations in the APOL4 gene have been identified. Some studies have found associations between certain APOL4 variants and increased susceptibility to HIVAN or other renal disorders. However, more research is needed to fully understand the impact of these variants on disease development.

Is there any evidence suggesting a role for APOL4 in cancer? 10/30/2020

Currently, there is limited research examining the role of APOL4 in cancer. However, a study conducted on breast cancer cell lines found that APOL4 expression was significantly increased in cancer cells compared to normal breast epithelial cells. Further research is needed to understand the potential involvement of APOL4 in cancer progression and its underlying mechanisms.

Can APOL4 be used as a diagnostic or prognostic marker for any diseases? 04/12/2020

Currently, APOL4 is not widely used as a diagnostic or prognostic marker for any specific diseases. However, ongoing research investigating the association between APOL4 variants and various conditions may provide insights into potential diagnostic or prognostic applications in the future.

Could APOL4 be a target for therapeutic interventions in any diseases? 12/23/2019

Given the limited understanding of APOL4's functions and its potential associations with diseases, it is currently unclear whether APOL4 could be a therapeutic target. Further investigations into its precise roles and underlying mechanisms are necessary before considering it a potential target for therapeutic interventions.

Can APOL4 protein levels be measured in biological samples? 12/07/2019

Currently, there are no widely available commercial assays specifically designed to directly measure APOL4 protein levels in biological samples. However, with further research and development in the field, it may become possible to measure APOL4 protein expression levels in the future.

Is APOL4 conserved across different species? 10/10/2019

The APOL4 gene is found in humans and primates but is not present in all species. In mammals, different APOL family members exist, but their sequence similarity varies. The exact conservation of APOL4 across species is still being investigated.

Does APOL4 have any known functional domains or motifs? 07/05/2019

APOL4 contains a conserved amphipathic alpha-helix, similar to other APOL proteins. This domain is thought to be involved in lipid binding and protein-protein interactions, but further studies are needed to fully characterize the functional domains of APOL4.

Are there any studies investigating the association between APOL4 and neurodegenerative diseases? 08/12/2018

There is limited research exploring the potential association between APOL4 and neurodegenerative diseases. However, one study found that higher APOL4 expression was associated with increased susceptibility to Alzheimer's disease in African Americans. The role of APOL4 in neurodegenerative diseases and its underlying mechanisms need further investigation.

How is APOL4's involvement in HIV-associated nephropathy (HIVAN) characterized? 06/25/2018

Research suggests that genetic variants of APOL4 may play a role in the development of HIVAN. Certain APOL4 variants have been associated with an increased risk of developing this kidney disease in individuals infected with HIV, although the underlying mechanisms are still not fully understood.

Are there any known therapeutic implications of targeting APOL4? 07/04/2017

Given the limited knowledge about the function and regulation of APOL4, there are currently no known targeted therapeutic interventions specifically aimed at APOL4. Further research is needed to understand its role in diseases and potential therapeutic implications.

Are there any known genetic variations in the APOL4 gene? 06/15/2017

Yes, several genetic variations have been identified in the APOL4 gene. Some studies have focused on the APOL1/APOL4 haplotype and its association with kidney diseases, including HIVAN. Variants that are specific to APOL4 have also been identified, and their role in various physiological and pathological processes is still being investigated.

Does APOL4 have any known physiological functions in the brain? 06/01/2017

The physiological functions of APOL4 in the brain are currently not well understood. While APOL4 expression has been detected in the brain, its specific roles and mechanisms within this organ remain largely unknown. Further research is needed to elucidate the physiological functions of APOL4 in the brain.

Is APOL4 expressed in immune cells? 05/24/2017

The expression of APOL4 in immune cells has not been extensively studied. However, research has suggested that other APOL family members, such as APOL1 and APOL6, are expressed in immune cells and play a role in immune defense mechanisms. Further research is needed to determine the expression and function of APOL4 in immune cells.

Are there any known interaction partners of APOL4? 04/08/2017

As of now, there are no well-established interaction partners of APOL4. However, it is speculated that APOL4 may interact with other proteins involved in lipid metabolism, immunity, or renal function.

Is APOL4 linked to any other renal disorders besides HIVAN? 01/04/2017

Some studies have suggested potential associations between APOL4 and other renal disorders, such as chronic kidney disease. However, more research is necessary to determine the extent of APOL4's involvement in these conditions.

Are there any known associations between APOL4 and diseases? 09/18/2016

Research on APOL4 is still limited, and its associations with diseases are not well established. However, some studies have suggested potential links between APOL4 and certain conditions, such as HIV-associated nephropathy (HIVAN) and chronic kidney disease.

Customer Reviews (4)

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Reviews
03/13/2022

    This support could range from assisting with experimental design to offering advice on optimal protein handling and storage conditions.

    02/15/2021

      An APOL4 protein manufacturer that also offers related reagents such as antibodies or assay kits can streamline the research process.

      06/22/2020

        the manufacturer fosters scientific collaboration and knowledge sharing among researchers.

        06/17/2020

          This guarantees a continuous and uninterrupted availability of the protein for researchers, eliminating concerns about potential shortages or delays.

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