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Recombinant Human ARC cell lysate

Cat.No. : ARC-106HCL
  • Specification
  • Gene Information
  • Related Products
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : ARC activity-regulated cytoskeleton-associated protein [ Homo sapiens ]
Official Symbol : ARC
Synonyms : ARC; activity-regulated cytoskeleton-associated protein; Arg3.1; KIAA0278; ARC/ARG3.1; activity-regulated gene 3.1 protein homolog;
Gene ID : 23237
mRNA Refseq : NM_015193
Protein Refseq : NP_056008
MIM : 612461
UniProt ID : Q7LC44
Chromosome Location : 8q24.3
Pathway : Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (15)

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Are there any genetic mutations or variations in the ARC gene associated with human diseases? 04/06/2023

To date, no genetic mutations or variations in the ARC gene have been directly linked to specific human diseases. However, dysregulation of ARC expression has been reported in multiple neurological disorders, as mentioned earlier. This suggests that alterations in the regulation or function of ARC, which may involve multiple genetic and environmental factors, could contribute to the development or progression of these disorders. Further research is needed to identify any specific genetic factors or variations that may be associated with ARC dysfunction in human diseases.

Is there any evidence suggesting a role for the ARC protein in addiction? 01/29/2023

Yes, emerging research suggests a potential role for the ARC protein in addiction. Animal studies have shown that chronic exposure to drugs of abuse impacts ARC expression in brain regions involved in reward and addiction. Furthermore, manipulating ARC levels in these brain regions can alter drug-seeking behaviors, indicating a possible involvement of ARC in the neurobiology of addiction.

Does the ARC protein have any non-neuronal functions? 01/03/2023

While the ARC protein is primarily studied in the context of brain function, recent studies have highlighted its presence and potential roles in non-neuronal cells. ARC expression has been observed in immune cells, skeletal muscle, and other tissues, suggesting its involvement in cellular processes beyond the central nervous system. However, the exact functions and implications of ARC in these non-neuronal contexts are still being explored.

How do researchers study the function of the ARC protein? 09/19/2022

Researchers use a variety of techniques to study the function of the ARC protein. These include genetic manipulation in animal models, such as knockout or overexpression of the Arc gene, to assess the impact on synaptic plasticity and behavior.

Are there any known mutations or genetic variations in the ARC gene? 02/13/2022

Yes, some studies have identified genetic variations in the ARC gene that are associated with neurological disorders. For example, single nucleotide polymorphisms (SNPs) in the ARC gene have been found to be associated with increased risk of schizophrenia. However, the functional implications of these variations and their direct effect on ARC protein function are still being investigated.

What are the consequences of ARC dysfunction in neurological disorders? 09/07/2021

Emerging evidence suggests that dysregulation or dysfunction of ARC may contribute to the pathophysiology of several neurological disorders. Altered ARC expression has been observed in conditions such as Alzheimer's disease, epilepsy, and schizophrenia. In these disorders, disrupted ARC levels or function may lead to impaired synaptic plasticity, abnormal neuronal connectivity, and synaptic dysfunction. However, the specific mechanisms and consequences of ARC dysfunction in each disorder are still under investigation.

Are there any inhibitors or activators of ARC expression or function? 10/15/2020

Currently, no specific inhibitors or activators of ARC expression or function have been developed. However, some studies have investigated the effects of manipulating intracellular signaling pathways and transcription factors that regulate ARC expression. For example, inhibiting the activation of kinases or blocking the binding of transcription factors to the Arc gene regulatory sequences can impact ARC expression. Further research is needed to identify and develop specific molecules that can selectively modulate ARC expression or function.

Can targeting the ARC protein be a potential therapeutic strategy for neurodegenerative diseases? 06/05/2019

Targeting the ARC protein has shown promising potential as a therapeutic strategy for neurodegenerative diseases. Studies using viral-mediated gene therapy to increase ARC expression have demonstrated neuroprotective effects and improved cognitive function in animal models of Alzheimer's disease and other neurodegenerative disorders. However, further research is needed to fully understand the therapeutic implications of ARC modulation in human diseases.

How is ARC involved in addiction-related behaviors? 02/01/2018

ARC has been implicated in addiction-related behaviors, particularly in the context of drug addiction. Studies have shown that ARC expression is altered in brain regions associated with reward and addiction, such as the nucleus accumbens and the prefrontal cortex. ARC is involved in the molecular and cellular changes that occur in the brain during drug addiction, including the remodeling of synapses and the modulation of dopamine signaling. Animal studies have demonstrated that manipulating ARC expression or function can impact drug-seeking behavior, suggesting its involvement in addictive behaviors. However, the specific mechanisms by which ARC contributes to addiction are still being elucidated.

What implications does the ARC protein have for neurodevelopmental disorders? 01/11/2018

The ARC protein has been implicated in neurodevelopmental disorders such as autism spectrum disorder (ASD). Studies have found that ARC expression levels are altered in individuals with ASD, suggesting a potential involvement of ARC in the pathophysiology of the disorder. Dysregulation of ARC may disrupt synaptic function and impair normal brain development.

Is the ARC protein involved in other cellular processes outside of the brain? 12/11/2017

Although the ARC protein is predominantly expressed in the brain, recent research suggests that it may also have roles in other cellular processes outside of the central nervous system. Studies have indicated its involvement in long-term potentiation of skeletal muscle and immune response regulation, highlighting its potential functions beyond synaptic plasticity.

Are there any known interactions between the ARC protein and other molecules or proteins? 03/28/2017

Yes, the ARC protein has been shown to interact with multiple molecules and proteins to regulate various cellular processes. One of its best-characterized interactions is with the neuronal activity-regulated immediate early gene (IEG) products, such as Homer1a, Egr1, and Egr2. ARC can form complexes with these proteins to modulate synaptic plasticity and regulate dendritic spine morphology. ARC has also been reported to interact with other synaptic proteins, ion channels, and scaffolding proteins, suggesting its involvement in the organization and regulation of synaptic networks.

What are the molecular mechanisms underlying the regulation of ARC protein expression? 07/15/2016

The regulation of ARC protein expression involves a complex network of signaling pathways and transcriptional control. Upon neuronal activity, calcium influx triggers the activation of various kinases, including ERK, PKA, and CaMKII, which in turn activate transcription factors such as CREB. These transcription factors bind to specific regulatory sequences on the Arc gene, promoting its transcription and subsequent translation into the ARC protein.

Can ARC be used as a biomarker for neurological disorders or addiction? 06/15/2016

The potential of ARC as a biomarker for neurological disorders or addiction is still under investigation. While altered ARC expression has been observed in various conditions, it remains to be seen whether measuring ARC levels or activity can serve as a reliable diagnostic or prognostic biomarker. Additionally, since ARC is a synaptic protein with diverse functions, it may be more informative to consider ARC in combination with other biomarkers or clinical assessments to better understand the underlying neurobiology of these disorders.

Have any therapeutic strategies been developed targeting the ARC protein? 02/22/2016

Currently, there are no specific therapeutic strategies targeting the ARC protein. However, the emerging understanding of its involvement in neurological disorders and addiction has opened up avenues for potential therapeutic interventions. For example, targeting the signaling pathways and transcription factors involved in ARC expression could potentially regulate its expression and function. Additionally, modulation of ARC's interaction with other proteins or downstream signaling molecules may also be explored as a therapeutic approach. However, further research is needed to fully understand the therapeutic potential and feasibility of targeting the ARC protein.

Customer Reviews (8)

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Reviews
02/19/2023

    the ARC protein offers exceptional quality.

    08/14/2022

      The manufacturer's responsive and knowledgeable support team is always available to answer my queries or provide guidance, ensuring that I can proceed with my research smoothly and without delays.

      11/16/2020

        This versatility allows me to explore different aspects of my research with confidence and accuracy.

        11/10/2020

          Its stability and purity make it an ideal candidate for studying protein structures at a high resolution, providing crucial insights into the organization and function of the ARC protein.

          08/18/2020

            It has consistently demonstrated outstanding results, consistently producing clear and sharp bands, allowing for accurate and reliable protein detection and quantification.

            11/10/2019

              As a researcher utilizing the ARC protein in my trials, I have experienced notable advantages that contribute to the efficiency and success of my research.

              08/29/2019

                I highly recommend the ARC protein for its exceptional performance in Western blot analysis.

                03/03/2019

                  They can provide technical assistance, ensuring optimal utilization of the product.

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