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Recombinant Human ARHGAP26 cell lysate

Cat.No. : ARHGAP26-111HCL
  • Specification
  • Gene Information
  • Related Products
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : ARHGAP26 Rho GTPase activating protein 26 [ Homo sapiens ]
Official Symbol : ARHGAP26
Synonyms : ARHGAP26; Rho GTPase activating protein 26; rho GTPase-activating protein 26; GRAF; GTPase regulator associated with the focal adhesion kinase pp125; KIAA0621; OPHN1L; OPHN1L1; oligophrenin-1-like protein; GTPase regulator associated with focal adhesion kinase pp125(FAK); GRAF1; FLJ42530;
Gene ID : 23092
mRNA Refseq : NM_001135608
Protein Refseq : NP_001129080
MIM : 605370
UniProt ID : Q9UNA1
Chromosome Location : 5q31
Pathway : Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by Rho GTPases, organism-specific biosystem; Signaling events mediated by focal adhesion kinase, organism-specific biosystem;
Function : GTPase activator activity; Rho GTPase activator activity; SH3 domain binding; cytoskeletal adaptor activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (11)

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Does ARHGAP26 have any known roles in neuronal development or synaptic function? 01/27/2023

While the majority of research on ARHGAP26 has focused on its function in cell migration and actin dynamics, emerging evidence suggests its involvement in neuronal development and synaptic morphology. ARHGAP26 has been implicated in dendritic spine formation and synaptic plasticity, indicating its potential roles in neuronal development and synaptic function.

Can ARHGAP26 be targeted therapeutically for any diseases? 07/25/2022

The therapeutic targeting of ARHGAP26 is currently not well-explored. However, given its involvement in cell migration and cytoskeletal dynamics, modulating ARHGAP26 activity or its downstream signaling pathways could hold potential for therapeutic intervention in diseases with aberrant cell migration or invasive behavior, such as certain cancers or fibrosis.

In which tissues or cell types is ARHGAP26 expressed? 02/25/2022

ARHGAP26 is widely expressed in various tissues and cell types, including the brain, heart, liver, lung, and immune cells.

Are there any animal models available to study ARHGAP26? 12/02/2019

Yes, several animal models have been developed to study the function of ARHGAP26. Knockout mouse models of ARHGAP26 have been generated and used to investigate its role in various physiological and pathological processes.

Is there any evidence of ARHGAP26 playing a role in cell migration or invasion? 12/02/2018

Yes, ARHGAP26 has been implicated in the regulation of cytoskeletal dynamics and cell migration. It interacts with various proteins involved in focal adhesions and actin remodeling, suggesting its involvement in cell migration and invasion processes.

Can ARHGAP26 mutations result in any genetic disorders? 09/26/2018

Yes, mutations in the ARHGAP26 gene have been associated with certain genetic disorders. For instance, mutations in ARHGAP26 have been linked to familial idiopathic pulmonary fibrosis (IPF), a progressive lung disease characterized by abnormal scarring of lung tissue.

How does ARHGAP26 regulate actin cytoskeleton dynamics? 04/27/2018

ARHGAP26 acts as a Rho GTPase-activating protein specifically for RhoA, leading to the inactivation of RhoA. By hydrolyzing the GTP bound to RhoA, ARHGAP26 helps switch RhoA from its active GTP-bound form to its inactive GDP-bound form. This inactivation of RhoA affects actin polymerization and rearrangement, ultimately regulating the dynamics of the actin cytoskeleton.

Can ARHGAP26 regulate endocytosis or vesicle trafficking processes? 10/03/2016

Yes, ARHGAP26 has been associated with endocytosis and vesicle trafficking. By interacting with the GTPase dynamin and intersectin, ARHGAP26 may participate in membrane invagination and vesicle scission during endocytosis. Its precise mechanisms and specific roles in these processes are still under investigation.

Are there any known binding partners or interacting proteins of ARHGAP26? 08/04/2016

Yes, ARHGAP26 can interact with various proteins involved in cell adhesion, actin remodeling, and membrane trafficking. Some of its known binding partners include focal adhesion kinase (FAK), phosphoinositide 3-kinase (PI3K), ephrin receptors, intersectin, and Cdc42-interacting protein 4 (CIP4).

Is ARHGAP26 involved in any cellular signaling pathways other than Rho GTPase signaling? 07/01/2016

ARHGAP26 primarily functions as a Rho GTPase-activating protein and is primarily involved in the regulation of Rho GTPase signaling. However, it may also participate in other cellular processes, such as endocytosis and vesicle trafficking.

Are there any known functional domains within the ARHGAP26 protein? 01/25/2016

Yes, ARHGAP26 contains several recognizable functional domains, including a RhoGAP domain responsible for RhoA GTPase activation, a Pleckstrin homology (PH) domain involved in protein interactions with phospholipids, an SH3 domain known to mediate protein-protein interactions, and a C2 domain potentially involved in membrane binding.

Customer Reviews (8)

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Reviews
12/17/2022

    With their meticulous documentation and support, I am confident that my utilization of ARHGAP26 protein in clinical trials will meet all necessary regulations and guidelines.

    11/17/2022

      Their ability to accommodate the requirements of large-scale experiments and guarantee a reliable supply streamlines my research operations, eliminating any concerns related to potential shortages.

      05/04/2022

        In ELISA assays, it has consistently exhibited exceptional reliability and accuracy, providing precise and reproducible results.

        03/18/2022

          I have successfully implemented the ARHGAP26 protein in protein electron microscopy structure analysis, where its attributes have greatly aided in elucidating complex molecular structures.

          04/13/2021

            I am confident that the protein will reliably perform in my assays, providing accurate and reproducible results.

            08/16/2020

              the manufacturer's supply management capabilities assure a seamless and continuous provision of the ARHGAP26 protein.

              04/24/2017

                Considering its remarkable performance across multiple assays, I wholeheartedly endorse the usage of the ARHGAP26 protein in various research studies.

                05/01/2016

                  when utilized in Western Blotting experiments, the ARHGAP26 protein has consistently produced distinct and well-defined protein bands, facilitating clear and accurate interpretation of results.

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