Recombinant Human ARTN cell lysate
Cat.No. : | ARTN-134HCL |
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Description : | The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | ARTN artemin [ Homo sapiens ] |
Official Symbol : | ARTN |
Synonyms : | ARTN; artemin; ENOVIN; EVN; NBN; neublastin; neurotrophic factor; |
Gene ID : | 9048 |
mRNA Refseq : | NM_001136215 |
Protein Refseq : | NP_001129687 |
MIM : | 603886 |
UniProt ID : | Q5T4W7 |
Chromosome Location : | 1p33-p32 |
Pathway : | Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; NCAM signaling for neurite out-growth, organism-specific biosystem; NCAM1 interactions, organism-specific biosystem; |
Function : | growth factor activity; receptor binding; |
Products Types
◆ Recombinant Protein | ||
ARTN-03H | Recombinant Human ARTN Protein | +Inquiry |
ARTN-006H | Active Recombinant Human ARTN Protein | +Inquiry |
Artn-853M | Recombinant Mouse Artn protein(Ala112-Gly224), hFc-tagged | +Inquiry |
ARTN-467R | Recombinant Rat ARTN Protein, His (Fc)-Avi-tagged | +Inquiry |
ARTN-703H | Recombinant Human ARTN Protein | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (8)
Ask a questionThe ARTN protein activates various signaling pathways, including the RET receptor tyrosine kinase pathway and the AKT and MAPK/ERK pathways, to mediate its neurotrophic effects.
Yes, the ARTN protein has neuroprotective effects and can promote the survival of neurons under conditions of stress or injury, such as oxidative stress or neuronal damage.
Dysregulation of the ARTN protein has been implicated in neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Further research is needed to understand the underlying mechanisms.
Yes, the ARTN protein is involved in the development of the nervous system. It plays a role in guiding growing axons and promoting the survival and differentiation of neurons during development.
The potential therapeutic use of the ARTN protein is being explored, particularly for neurodegenerative diseases, but further research is needed to evaluate its effectiveness and safety.
Yes, the ARTN protein has immunomodulatory properties. It can influence immune cell activity and promote anti-inflammatory responses in certain contexts.
As of now, no specific mutations in the ARTN gene linked to neurological disorders have been reported. However, ongoing genomic studies might uncover any potential disease associations.
Yes, the ARTN protein has been implicated in pain perception. It has been shown to influence the sensitivity of sensory neurons and modulate pain signaling pathways.
Customer Reviews (3)
Write a reviewI highly endorse the utilization of the ARTN Protein for researchers seeking a superior protein solution that not only meets their experimental needs but also benefits from the exceptional technical support provided by the manufacturer.
Their team of experts has been extremely helpful in addressing any concerns or queries I encountered during my experiments.
Its exceptional purity and consistency have consistently yielded reliable and reproducible results, ensuring the accuracy and reliability of my research outcomes.
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