Cat.No.:	ARTN-134HCL
Description:	The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Species:	Human
Size:	100 ul
Storage Buffer:	1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications:	Western Blot;

Gene Name:	ARTN artemin [ Homo sapiens ]
Official Symbol:	ARTN
Synonyms:	ARTN; artemin; ENOVIN; EVN; NBN; neublastin; neurotrophic factor;
Gene ID:	9048
mRNA Refseq:	NM_001136215
Protein Refseq:	NP_001129687
MIM:	603886
UniProt ID:	Q5T4W7
Chromosome Location:	1p33-p32
Pathway:	Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; NCAM signaling for neurite out-growth, organism-specific biosystem; NCAM1 interactions, organism-specific biosystem;
Function:	growth factor activity; receptor binding;

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