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Recombinant Human CBL cell lysate

Cat.No.: CBL-287HCL
Description: The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Species: Human
Size: 100 ul
Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications: Western Blot;
Gene Name: CBL Cbl proto-oncogene, E3 ubiquitin protein ligase [ Homo sapiens ]
Official Symbol: CBL
Synonyms: CBL; Cbl proto-oncogene, E3 ubiquitin protein ligase; Cas Br M (murine) ecotropic retroviral transforming sequence , CBL2; E3 ubiquitin-protein ligase CBL; c Cbl; oncogene CBL2; RNF55; proto-oncogene c-Cbl; RING finger protein 55; signal transduction protein CBL; casitas B-lineage lymphoma proto-oncogene; Cas-Br-M (murine) ecotropic retroviral transforming sequence; CBL2; NSLL; C-CBL;
Gene ID: 867
mRNA Refseq: NM_005188
Protein Refseq: NP_005179
MIM: 165360
UniProt ID: P22681
Chromosome Location: 11q23.3-qter
Pathway: Adaptive Immune System, organism-specific biosystem; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; CDC42 signaling events, organism-specific biosystem; Chronic myeloid leukemia, organism-specific biosystem;
Function: SH3 domain binding; calcium ion binding; ephrin receptor binding; ligase activity; phosphotyrosine binding; protein binding; sequence-specific DNA binding transcription factor activity; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding;

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