Recombinant Human CENPB cell lysate


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Recombinant Human CENPB cell lysate

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Cat.No. : CENPB-333HCL
Description : This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : CENPB centromere protein B, 80kDa [ Homo sapiens ]
Official Symbol : CENPB
Synonyms : CENPB; centromere protein B, 80kDa; centromere protein B (80kD); major centromere autoantigen B; CENP-B; centromere autoantigen B;
Gene ID : 1059
mRNA Refseq : NM_001810
Protein Refseq : NP_001801
MIM : 117140
UniProt ID : P07199
Chromosome Location : 20p13
Pathway : FOXM1 transcription factor network, organism-specific biosystem;
Function : DNA binding; centromeric DNA binding; chromatin binding; chromatin binding; satellite DNA binding; sequence-specific DNA binding;

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