Recombinant Human CENPB cell lysate

• Cat.No.: CENPB-333HCL

Specification

• Description: This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: CENPB centromere protein B, 80kDa [ Homo sapiens ]
• Official Symbol: CENPB
• Synonyms: CENPB; centromere protein B, 80kDa; centromere protein B (80kD); major centromere autoantigen B; CENP-B; centromere autoantigen B
• Gene ID: 1059
• mRNA Refseq: NM_001810
• Protein Refseq: NP_001801
• MIM: 117140
• UniProt ID: P07199
• Chromosome Location: 20p13
• Pathway: FOXM1 transcription factor network, organism-specific biosystem
• Function: DNA binding; centromeric DNA binding; chromatin binding; chromatin binding; satellite DNA binding; sequence-specific DNA binding