Recombinant Human FGA cell lysate

• Cat.No.: FGA-618HCL

Specification

• Description: The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: FGA fibrinogen alpha chain [ Homo sapiens ]
• Official Symbol: FGA
• Synonyms: FGA; fibrinogen alpha chain; fibrinogen, A alpha polypeptide; Fib2; MGC119422; MGC119423; MGC119425
• Gene ID: 2243
• mRNA Refseq: NM_000508
• Protein Refseq: NP_000499
• UniProt ID: P02671
• Chromosome Location: 4q28
• Pathway: Amyloids, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Disease, organism-specific biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem
• Function: eukaryotic cell surface binding; protein binding; protein binding, bridging; receptor binding