Recombinant Human NXN cell lysate
Cat.No. : | NXN-1239HCL |
- Specification
- Gene Information
- Related Products
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | NXN nucleoredoxin [ Homo sapiens ] |
Official Symbol : | NXN |
Synonyms : | NXN; nucleoredoxin; FLJ12614; NRX; nucleoredoxin 1; TRG-4; |
Gene ID : | 64359 |
mRNA Refseq : | NM_001205319 |
Protein Refseq : | NP_001192248 |
MIM : | 612895 |
UniProt ID : | Q6DKJ4 |
Chromosome Location : | 17p13 |
Function : | oxidoreductase activity; protein-disulfide reductase activity; thioredoxin-disulfide reductase activity; |
Products Types
◆ Recombinant Protein | ||
NXN-6286M | Recombinant Mouse NXN Protein, His (Fc)-Avi-tagged | +Inquiry |
Nxn-4562M | Recombinant Mouse Nxn Protein, Myc/DDK-tagged | +Inquiry |
NXN-1973H | Recombinant Human NXN Protein, MYC/DDK-tagged | +Inquiry |
NXN-1567H | Recombinant Human NXN Protein, His (Fc)-Avi-tagged | +Inquiry |
Nxn-775M | Recombinant Mouse Nxn Protein, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionThe applications of NXN in tumor treatment include: (1) direct killing of tumor cells and inhibition of tumor growth by carrying chemotherapy drugs, siRNAs, etc.; (2) enhanced immunotherapy, which enhances the body's immune response by carrying immunomodulators or vaccines, (3) anti-angiogenic therapy, which inhibits tumor angiogenesis by inhibiting the expression of angiogenesis, and (4) radiotherapy sensitization, which improves the effect of radiotherapy by carrying radioisotopes.
NXN has the following advantages: (1) high drug loading capacity, which can achieve precise drug delivery, (2) biocompatibility and biodegradability, and no toxic side effects to the body, (3) it can achieve sustained and controlled release of drugs to improve the effect of drug treatment, and (4) it has tumor targeting and cell membrane penetration, which can be used for tumor treatment.
The preparation methods of NXN include physicochemical methods and biochemical methods. Among them, the physical and chemical methods include nanoimprint, nanotemplate method, solvent volatilization method and emulsion method, and the biochemical methods include molecular self-assembly, gene coding and cell membrane coating. These methods can be prepared according to the specific application needs.
The performance of NXN is mainly evaluated by the following aspects: (1) particle size and morphology analysis, which is characterized by nanoparticle size analyzer, scanning electron microscopy and transmission electron microscopy, (2) drug loading and release performance, which is evaluated by drug content determination and in vitro release experiments, (3) biocompatibility and safety evaluation, cytotoxicity experiments, acute toxicity experiments and immunogenicity evaluation, etc., (4) targeting and in vivo distribution, Fluorescence imaging techniques and other methods to observe.
In addition to oncology treatment, NXN can also be used in other areas of drug delivery. For example, NXN is used in gene therapy as a carrier for gene drugs such as siRNA and miRNA, NXN is used in antimicrobial therapy as a carrier for antibiotic drugs, and NXN is used in the treatment of neurodegenerative diseases as a carrier for neuroprotective drugs.
The effect of NXN in tumor treatment is mainly evaluated through the following aspects: (1) tumor growth inhibition effect, observing the growth of tumor after NXN treatment, (2) survival evaluation, observing the survival time of animals after NXN treatment, (3) enhancing immune response effect, detecting the changes of immune indicators of the body after NXN treatment, and (4) safety evaluation, detecting the toxicity and side effects of animals after NXN treatment.
Customer Reviews (3)
Write a reviewIt has good stability in different environments, with thermal stability, acid and alkali stability.
The storage method is simple, and there is no need to prepare a special environment.
It is highly safe and can be used with confidence.
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