Recombinant Human PLOD3 cell lysate

• Cat.No.: PLOD3-1379HCL

Specification

• Description: The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 [ Homo sapiens ]
• Official Symbol: PLOD3
• Synonyms: PLOD3; procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3; procollagen-lysine,2-oxoglutarate 5-dioxygenase 3; LH3; lysyl hydroxlase 3; lysyl hydroxylase 3; lysine hydroxylase 3
• Gene ID: 8985
• mRNA Refseq: NM_001084
• Protein Refseq: NP_001075
• MIM: 603066
• UniProt ID: O60568
• Chromosome Location: 7q22.1
• Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Other types of O-glycan biosynthesis, organism-specific biosystem; Other types of O-glycan biosynthesis, conserved biosystem
• Function: L-ascorbic acid binding; iron ion binding; metal ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; procollagen glucosyltransferase activity; procollagen-lysine 5-dioxygenase activity; protein binding