"PMS2" Related Products

Recombinant Human PMS2 cell lysate

Cat.No.: PMS2-1383HCL
Description: This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
Species: Human
Size: 100 ul
Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications: Western Blot;
Gene Name: PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) [ Homo sapiens ]
Official Symbol: PMS2
Synonyms: PMS2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae); PMSL2, postmeiotic segregation increased (S. cerevisiae) 2; mismatch repair endonuclease PMS2; H_DJ0042M02.9; HNPCC4; PMS1 protein homolog 2; DNA mismatch repair protein PMS2; PMSL2; PMS2CL;
Gene ID: 5395
mRNA Refseq: NM_000535
Protein Refseq: NP_000526
MIM: 600259
UniProt ID: P54278
Chromosome Location: 7p22.1
Pathway: BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Mismatch repair, organism-specific biosystem; Mismatch repair, conserved biosystem;
Function: ATP binding; ATPase activity; DNA binding; contributes_to MutSalpha complex binding; endonuclease activity; hydrolase activity; mismatched DNA binding; protein binding; single base insertion or deletion binding; contributes_to single-stranded DNA binding;

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