Recombinant Human PMS2 cell lysate

• Cat.No.: PMS2-1383HCL

Specification

• Description: This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: PMS2
• Synonyms: PMS2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae); PMSL2, postmeiotic segregation increased (S. cerevisiae) 2; mismatch repair endonuclease PMS2; H_DJ0042M02.9; HNPCC4; PMS1 protein homolog 2; DNA mismatch repair protein PMS2; PMSL2; PMS2CL
• Gene ID: 5395
• mRNA Refseq: NM_000535
• Protein Refseq: NP_000526
• MIM: 600259
• UniProt ID: P54278
• Chromosome Location: 7p22.1
• Pathway: BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Mismatch repair, organism-specific biosystem; Mismatch repair, conserved biosystem
• Function: ATP binding; ATPase activity; DNA binding; contributes_to MutSalpha complex binding; endonuclease activity; hydrolase activity; mismatched DNA binding; protein binding; single base insertion or deletion binding; contributes_to single-stranded DNA binding