"POLH" Related Products

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Recombinant Human POLH cell lysate

Cat.No.: POLH-1392HCL
Description: This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.
Species: Human
Size: 100 ul
Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications: Western Blot;
Gene Name: POLH polymerase (DNA directed), eta [ Homo sapiens ]
Official Symbol: POLH
Synonyms: POLH; polymerase (DNA directed), eta; DNA polymerase eta; RAD30A; XP V; RAD30 homolog A; xeroderma pigmentosum variant type protein; XPV; XP-V; RAD30; FLJ16395; FLJ21978;
Gene ID: 5429
mRNA Refseq: NM_006502
Protein Refseq: NP_006493
MIM: 603968
UniProt ID: Q9Y253
Chromosome Location: 6p21
Pathway: DNA Damage Bypass, organism-specific biosystem; DNA Repair, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Translesion synthesis by DNA polymerases bypassing lesion on DNA template, organism-specific biosystem; Translesion synthesis by Pol eta, organism-specific biosystem;
Function: DNA-directed DNA polymerase activity; DNA-directed DNA polymerase activity; damaged DNA binding; metal ion binding; nucleotidyltransferase activity; transferase activity;

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