Recombinant Human POLH cell lysate

• Cat.No.: POLH-1392HCL

Specification

• Description: This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: POLH polymerase (DNA directed), eta [ Homo sapiens ]
• Official Symbol: POLH
• Synonyms: POLH; polymerase (DNA directed), eta; DNA polymerase eta; RAD30A; XP V; RAD30 homolog A; xeroderma pigmentosum variant type protein; XPV; XP-V; RAD30; FLJ16395; FLJ21978
• Gene ID: 5429
• mRNA Refseq: NM_006502
• Protein Refseq: NP_006493
• MIM: 603968
• UniProt ID: Q9Y253
• Chromosome Location: 6p21
• Pathway: DNA Damage Bypass, organism-specific biosystem; DNA Repair, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Translesion synthesis by DNA polymerases bypassing lesion on DNA template, organism-specific biosystem; Translesion synthesis by Pol eta, organism-specific biosystem
• Function: DNA-directed DNA polymerase activity; DNA-directed DNA polymerase activity; damaged DNA binding; metal ion binding; nucleotidyltransferase activity; transferase activity