Recombinant Full Length Human POLH Protein, C-Flag-tagged
Cat.No. : | POLH-1886HFL |
Product Overview : | Recombinant Full Length Human POLH Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 78.2 kDa |
AA Sequence : | MATGQDRVVALVDMDCFFVQVEQRQ NPHLRNKPCAVVQYKSWKGGGIIAV SYEARAFGVTRSMWADDAKK LCPDLLLAQVRESRGKANLTKYREA SVEVMEIMSRFAVIERASIDEAYVD LTSAVQERLQKLQGQPISAD LLPSTYIEGLPQGPTTAEETVQKEG MRKQGLFQWLDSLQIDNLTSPDLQL TVGAVIVEEMRAAIERETGF QCSAGISHNKVLAKLACGLNKPNRQ TLVSHGSVPQLFSQMPIRKIRSLGG KLGASVIEILGIEYMGELTQ FTESQLQSHFGEKNGSWLYAMCRGI EHDPVKPRQLPKTIGCSKNFPGKTA LATREQVQWWLLQLAQELEE RLTKDRNDNDRVATQLVVSIRVQGD KRLSSLRRCCALTRYDAHKMSHDAF TVIKNCNTSGIQTEWSPPLT MLFLCATKFSASAPSSSTDITSFLS SDPSSLPKVPVTSSEAKTQGSGPAV TATKKATTSLESFFQKAAER QKVKEASLSSLTAPTQAPMSNSPSK PSLPFQTSQSTGTEPFFKQKSLLLK QKQLNNSSVSSPQQNPWSNC KALPNSLPTEYPGCVPVCEGVSKLE ESSKATPAEMDLAHNSQSMHASSAS KSVLEVTQKATPNPSLLAAE DQVPCEKCGSLVPVWDMPEHMDYHF ALELQKSFLQPHSSNPQVVSAVSHQ GKRNPKSPLACTNKRPRPEG MQTLESFFKPLTH TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Gene Name : | POLH DNA polymerase eta [ Homo sapiens (human) ] |
Official Symbol : | POLH |
Synonyms : | XPV; XP-V; RAD30; RAD30A |
Gene ID : | 5429 |
mRNA Refseq : | NM_006502.3 |
Protein Refseq : | NP_006493.1 |
MIM : | 603968 |
UniProt ID : | Q9Y253 |
Products Types
◆ Recombinant Protein | ||
POLH-6910M | Recombinant Mouse POLH Protein, His (Fc)-Avi-tagged | +Inquiry |
POLH-1730H | Recombinant Human POLH Protein, His (Fc)-Avi-tagged | +Inquiry |
Polh-4989M | Recombinant Mouse Polh Protein, Myc/DDK-tagged | +Inquiry |
POLH-2456H | Recombinant Human POLH Protein, MYC/DDK-tagged | +Inquiry |
POLH-3733Z | Recombinant Zebrafish POLH | +Inquiry |
◆ Lysates | ||
POLH-1392HCL | Recombinant Human POLH cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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