Recombinant Human PTPRN2 cell lysate

• Cat.No.: PTPRN2-1441HCL

Specification

• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 [ Homo sapiens ]
• Official Symbol: PTPRN2
• Synonyms: PTPRN2; protein tyrosine phosphatase, receptor type, N polypeptide 2; receptor-type tyrosine-protein phosphatase N2; IA 2beta; IAR PTPRP; ICAAR; KIAA0387; phogrin; tyrosine phosphatase IA-2 beta; islet cell autoantigen-related protein; protein tyrosine phosphatase receptor pi; IAR/receptor-like protein-tyrosine phosphatase; IAR; PTPRP; IA-2beta; R-PTP-N2
• Gene ID: 5799
• mRNA Refseq: NM_002847
• Protein Refseq: NP_002838
• MIM: 601698
• UniProt ID: Q92932
• Chromosome Location: 7q36
• Pathway: Type I diabetes mellitus, organism-specific biosystem; Type I diabetes mellitus, conserved biosystem
• Function: hydrolase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase activity