"RASGRP4" Related Products


Recombinant Human RASGRP4 cell lysate

Cat.No.: RASGRP4-1477HCL
Description: The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene.
Species: Human
Size: 100 ul
Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications: Western Blot;
Gene Name: RASGRP4 RAS guanyl releasing protein 4 [ Homo sapiens ]
Official Symbol: RASGRP4
Synonyms: RASGRP4; RAS guanyl releasing protein 4; RAS guanyl-releasing protein 4; guanyl nucleotide releasing protein 4;
Gene ID: 115727
mRNA Refseq: NM_001146202
Protein Refseq: NP_001139674
MIM: 607320
UniProt ID: Q8TDF6
Chromosome Location: 19q13.1
Pathway: MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem;
Function: GTP-dependent protein binding; Ras guanyl-nucleotide exchange factor activity; diacylglycerol binding; metal ion binding;

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