"SIGLEC12" Related Products

Recombinant Human SIGLEC12 cell lysate

Cat.No.: SIGLEC12-1605HCL
Description: Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
Species: Human
Size: 100 ul
Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications: Western Blot;
Gene Name: SIGLEC12 sialic acid binding Ig-like lectin 12 (gene/pseudogene) [ Homo sapiens ]
Official Symbol: SIGLEC12
Synonyms: SIGLEC12; sialic acid binding Ig-like lectin 12 (gene/pseudogene); sialic acid binding Ig like lectin 12 , SIGLEC like 1 , SIGLECL1; sialic acid-binding Ig-like lectin 12; S2V; Siglec 12; Siglec L1; Siglec XII; SLG; SIGLEC-like 1; sialic acid-binding Ig-like lectin-like 1; SIGLECL1; Siglec-XII; FLJ38600;
Gene ID: 89858
mRNA Refseq: NM_033329
Protein Refseq: NP_201586
MIM: 606094
UniProt ID: Q96PQ1
Chromosome Location: 19q13.41
Function: sugar binding;

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