Recombinant Human TIRAP cell lysate

• Cat.No.: TIRAP-1782HCL

Specification

• Description: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein [ Homo sapiens ]
• Official Symbol: TIRAP
• Synonyms: TIRAP; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Toll interleukin 1 receptor (TIR) domain containing adaptor protein; toll/interleukin-1 receptor domain-containing adapter protein; Mal; MyD88 adapter like; wyatt; adapter protein wyatt; adaptor protein Wyatt; MyD88 adapter-like protein; Toll-like receptor adaptor protein; BACTS1; FLJ42305
• Gene ID: 114609
• mRNA Refseq: NM_001039661
• Protein Refseq: NP_001034750
• MIM: 606252
• UniProt ID: P58753
• Chromosome Location: 11q24.2
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem; Pertussis, organism-specific biosystem; Pertussis, conserved biosystem; Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem
• Function: Toll-like receptor 2 binding; Toll-like receptor 4 binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein binding, bridging; protein heterodimerization activity; protein homodimerization activity; protein kinase C binding